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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 129
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Concomitant exposure of bacoside A and bromelain relieves dichlorvos toxicity in mice serum
Sonam Agarwal and Renu Bist
Banasthali University, India
C urrent study emphasizes the toxic effects of dichlorvos on serum in terms of oxidative stress. Meanwhile, a protective
action of bacoside A and bromelain was investigated against the biochemical alterations in serum. Experimental design
included six groups of mice: Saline was given as a vehicle to the control mice (group I). Mice belonging to groups II, III
and IV were administered with dichlorvos (40 mg/kg b.w.), bromelain and bacoside A, respectively. Fifth group received a
combination of bromelain and bacoside A. In group VI, bacoside A and bromelain were administered 20 minutes prior to
exposure of dichlorvos. Thiobarbituric acid reactive substances (TBARS), protein carbonyl content (PCC), catalase (CAT),
superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH) level were used as biochemical
test of toxic action for dichlorvos intoxication. Significantly increased TBARS and PCC level in second group suggests that
dichlorvos enhances the production of free radicals in serum of mice (p<0.05). Antioxidants treatment significantly decreased
the levels of TBARS and PCC (p<0.05). Dichlorvos administration causes a significant reduction in the level of CAT, SOD,
GPx and GSH (p<0.05) which was restored significantly by co-administration of bromelain and bacoside A in dichlorvos
exposed mice (p<0.05). Treatment of bromelain and bacoside A in combination served as better scavengers of toxicity induced
by dichlorvos.
Biography
Sonam Agarwal is pursuing PhD in Biotechnology from Department of Bioscience and Biotechnology, Banasthali University, Rajasthan, India. She has completed
her MSc in Biotechnology from MITS University, Rajasthan, India. Her research work highlights “The role of bacoside A and bromelain against dichlorvos incited
toxicity in serum and kidneys of mice”.
Sonam Agarwal et al., J Clin Toxicol 2016, 6:6(Suppl)