euro-toxicology-2016_scientifictracks-abstracts

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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 104
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
The effect of proton pump inhibitors on bone mineral density in rats
Layla Ezzat Borham1,2, Magda M Hagras3, Altaf Abdulkhaliq1 and Mohammed Badawood4
1Umm Al-Qura University, Saudi Arabia
2Cairo University, Egypt
3Suez Canal University, Egypt
4King Abdul Aziz University, Saudi Arabia
Background: Increased con¬cerns rose towards the side effects of chronic use of proton pump inhibitors (PPIs).The relationship
between prolonged use of PPIs and bone metabolism is still not totally established.
Aim: Aim of this study is to examine the association between the use of (PPIs) and the risk of development osteoporosis.
Method: 180 adult male rats were assigned to three groups (60 rats each). Group I served as control; whereas, group II (a,
b), (i.p) omeprazole 20 mg/kg/day was administered for four and eight weeks respectively; group III (a, b), (i.p) omeprazole
40 mg/kg/day was given for the same period. At the end of drug treatment, 20 rats from each subgroup were examined for
bone mineral density (BMD), bone mineral content (BMC), serum calcium, phosphorus, parathormone, tartrate resistant acid
phosphatase type 5b (TRACP5b), insulin-like growth factor 1(1GF-1) and osteoprotegerin (OPG). The remaining 10 rats from
each subgroup were left without treatment for the next four weeks to detect the reversal effects of the drug.
Results: BMD and BMC decreased in a dose and time dependent manners with recovery. Serum calcium and phosphate
decreased at the dose 40 mg/kg for eight weeks with recovery of calcium after discontinuation of therapy but not phosphate.
Parathormone increased compared to control with no recovery. TRACP5b increased at 20, 40 mg at eight weeks with no
recovery. IGF1 decreased in dose and time dependent manner, recovery only for 20 mg for four weeks. OPG showed no change.
Conclusion: The chronic use of high doses of omeprazole could adversely affect bone homeostasis.
Biography
Layla Ezzat Borham is a Professor of Clinical Pharmacology at Cairo and UmmAl-Qura Universities since 2004. She completed his MSc and MD at Cairo University
Medical School. She has been working in Faculty of Medicine, Umm Al-Qura University, KSA for 15 years. During this period, she carried out a lot of scientific
and social serving activities through her publications, scientific committee memberships, lectures and administrative work. In addition, she works in the Ministry of
Health hospitals and primary health care centres giving awareness lectures to health care providers and patients. She has been awarded a Golden Prize from Umm
Al-Qura University for her overall services at the University.
Layla Ezzat Borham et al., J Clin Toxicol 2016, 6:6(Suppl)