euro-toxicology-2016_scientifictracks-abstracts

62 / 89

Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 103
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Effects of lornoxicam and intravenous ibuprofen on erythrocyte deformability liver and renal
blood flow in rats
Ayşegül Küçük1, Hande Arpacı3, Faruk Metin Çomu2, Bahadır Kösem 4, Seyfi Kartal4, Volkan Şıvgın 3, Hüseyin Cihad Turgut5, Muhammed Enes Aydın3,
Derya Sebile Koç3 and Mustafa Arslan3
1Kütahya Dumlupınar University, Turkey
2Kırıkkale University, Turkey
3Ankara University, Turkey
4Turgut Özal University Hospital, Turkey
5Gazi University, Turkey
C hange in blood supply is responsible for anesthesia related abnormal tissue and organ perfusion. Decreased erythrocyte
deformability and increased aggregation may be detected after surgery performed under general anesthesia. It was shown
that non-steroidal anti-inflammatory drugs decrease erythrocyte deformability. Lornoxicam and/or ibuprofen intravenous
administration for postoperative pain management is becoming more common. In this study, we aimed to investigate effects of
lornoxicam (2 mg/kg) and ibuprofen (30 mg/kg) on erythrocyte deformabil-ity, liver and renal blood flow in male rats. 18 male
Wistar albino rats were randomly divided into three groups as lornoxicam group (group L), ibuprofen group (group İ) and
control group (group C). İntravenous administrations were done in all groups except group C. Liver and renal blood flows were
conducted by laser Doppler and the euthanasia via intra-abdominal blood uptake was performed. Erythrocyte deformability
was measured using a constant flow filtrometry system. Lornoxicam and ibuprofen increased the relative resistance which
shows the erythrocyte deformability of rats (p=0.016). Comparison of group L and group I revealed no statistically dif-ferent
results (p=0.694) where group L and group I revealed statistically higher results than group C (p=0.018, p=0.008). Liver and
renal blood flows were significantly lower than that measured in group C. We believe that lornoxicam and ibuprofen may lead
to functional disorders related to tissue perfusion as a result of both decreased blood flow and erythrocyte deformability. Fur-
ther studies regarding these issues are thought to be essential.
Biography
Ayşegül Küçük has completed her PhD from Erciyes University and Post-doctoral studies from Erciyes University School of Medicine. She is a member in Depart-
ment of Physiology at the Medical Faculty of Dumlupinar University. She has published more than 25 papers in reputed journals.
Ayşegül Küçük et al., J Clin Toxicol 2016, 6:6(Suppl)