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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 102
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Nutraceuticals for hypertension care: A network based approach
Matteo Micucci, Chiarini A and Budriesi R
University of Bologna, Italy
S everal diseases with a high incidence including those pertaining cardiovascular system, are due to modifications of many
molecular networks influencing each other’s. The network based approach is based on the strategy named “network target
multi components” and “network target single chemical” strategies. In different traditional systems, including Traditional
Chinese Medicine (TCM) and ayurveda, poly-herbal formulations are considered efficient approaches to the treatment of
multifactorial diseases. Nutraceutical science is mainly aimed at identifying the chemical composition and the mechanisms of
action of complex mixtures, including the vegetal extracts. In this study, we focused on primary hypertension, representing a
multifactorial pathology strongly predisposing to cardiovascular events. Many vegetal extracts with antihypertensive activities
modulate several targets determining multiple cardiovascular beneficial effects. Among others, extracts from Olea europaea
L. leaves and Hibiscus sabdariffa L. flowers interfere with different pathways, producing a hypotensive activity. In this work,
we evaluated the cardiovascular effects and the toxicological profile of a Nutraceutical Formulation (NF) based on a mixture
of a Olea europaea L. leaves extract (OEE) and a Hibiscus sabdariffa L. flowers extract (HSE) in the ratio of 13:2 using in vitro
biological assays. The NF exerted a vasorelaxant effect (IC50=2.38mg/mL) and a negative chronotropic effect (IC50=1.04mg/
mL) at concentrations lower than those producing smooth muscle spontaneous contractility alterations in the other organs.
These experimental data suggest a potential application of this food supplement for contributing and managing preclinical
hypertension.
Biography
Matteo Micucci completed his graduation in Pharmacy at Bologna University. In 2010, he worked in the laboratory of Dr. RRJ Arroo, Leicester School of Pharmacy,
De Montfort University, UK. He was a Guest Scientist in the Department of Chemistry of Natural Substances, University of Naples “Federico II”, Italy. He awarded
European PhD in Pharmaceutical Sciences at Bologna University in 2012. He is a Scientific Consultant, in the field of Nutraceutical, Alternative and Complementary
Medicines, at Segreteria Particolare of a Senator of the Italian Republic. He is a Research Fellow Scientist at Department of Pharmacy and Biotechnology,
University of Bologna.
Matteo Micucci et al., J Clin Toxicol 2016, 6:6(Suppl)