euro-toxicology-2016_scientifictracks-abstracts

40 / 89

Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 81
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
A 52-week safety study in Cynomolgus macaque for genetically modified rice expressing
Cry1Ab/1Ac protein
Qing Xia
National Center of Biomedical Analysis, China
A52-week feeding study in Cynomolgus macaques was carried out to evaluate the safety of Bt-rice Huahui 1 (HH1), a
transgenic rice line expressing Cry1Ab/1Ac protein. Monkeys were fed a diet with 20% or 60% HH1 rice, 20% or 60%
parental rice (Minghui 63, MH63), normal diet, normal diet spiked with purified recombinant Cry1Ab/1Ac fusion protein or
bovine serum albumin (BSA) respectively. During the feeding trail, clinical observations were conducted daily, and multiple
parameters, including body weight, body temperature, electrocardiogram, hematology, blood biochemistry, serummetabolome
and gut microbiome were examined at regular intervals. Upon sacrifice, the organs were weighted, and the macroscopic,
microscopic and electron microscopic examinations were performed. The results show no adverse or toxic effects of Bt-rice
HH1 or Cry1Ab/1Ac fusion protein on monkeys. Therefore, the present 52-week primate feeding study suggests that the
transgenic rice containing Cry1Ab/1Ac is equivalent to its parental rice line MH63.
Biography
Qing Xia has completed her PhD from the Second Military Medical University and Post-doctoral studies from Duke University School of Medicine. She is the Vice
Director of National Center of Biomedical Analysis, Beijing, China. She has published more than 20 papers in reputed journals and has been serving as a Member
of the Chinese Committee of Bio-Safety on Transgenic Products.
Qing Xia, J Clin Toxicol 2016, 6:6(Suppl)