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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 87
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Reactive oxygen species (ROS), oxidative stress and antioxidants: Enzyme mimetic selenium
compounds as redox regulators
Govindasamy Mugesh
Indian Institute of Science, India
Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the biological
system’s ability to detoxify these reactive intermediates. It is well known that oxidative stress is responsible for several
disease states. Both Type I and II diabetics display increased levels of ROS such as free radicals and the onset of diabetes is
closely associated with oxidative stress. It has also been associated with diverse diseases, including cancer, renal disease and
neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Although plants and animals maintain the level of
antioxidants, such as glutathione (GSH), vitamins C, A and E as well as enzymes such as catalase, superoxide dismutase and
various peroxidases, insufficient levels of antioxidants, or inhibition of the antioxidant enzymes, cause oxidative stress. Our
group focuses on the development of enzyme mimetic redox modulators that can be used as drugs for diseases associated with
enhanced level of ROS and that can combat oxidative stress without affecting the cellular antioxidant systems. In this lecture,
various selenium compounds and their effect on ROS in mammalian cells will be discussed.
Biography
Govindasamy Mugesh received his PhD in 1998 from the Indian Institute of Technology, Bombay. He is an author of more than 120 publications in international peer
reviewed journals. He received several awards and recognitions. His research interests include the chemistry of thyroid hormone metabolism and development
of novel therapeutics for endothelial dysfunction and neurodegenerative diseases. He serves in the editorial boards of Organic & Biomolecular Chemistry, ACS
Omega, Bioorganic Chemistry and Scientific Reports.
Govindasamy Mugesh, J Clin Toxicol 2016, 6:6(Suppl)