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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal Euro Toxicology 2016
October 24-26, 2016
Page 68
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Vesna Matovic, J Clin Toxicol 2016, 6:6(Suppl)
Vesna Matovic
University of Belgrade, Serbia
Co-treatment with PCBs potenciates Cd nephrotoxicity
The nephrotoxic effect of cadmium (Cd) and polychlorinated biphenyls (PCBs), as widely spread toxic environmental
pollutants that enter food chain and pose risk to human health, was investigated and compared with Cd—agent of well-
known nephrotoxicity. Six groups of rats were receiving 0.3, 0.6, 1.25, 2.5, 5 or 10 mg Cd/kg b.w./day as aqueous solutions of
CdCl2, while nine groups were treated with different dose combinations of Cd and PCBs, as Aroclor 1254 dissolved in corn oil,
(1.25, 2.5 or 5 mg Cd/kg b.w./day with 2,4 or 8 mg PCBs/kg b.w./day). Two groups receiving only water or corn oil served as
controls. Treatment of all animals was performed by oral gavage and lasted for 28 days. Cadmium levels were determined in
blood and kidneys. Urea and creatinine in serum and relative kidney weight were determined. Blood and kidney Cd levels in
groups treated with Cd only as well as in co-treated groups were significantly higher if compared with controls, although PCBs
did not exert significant effect on Cd content. Urea levels were significantly higher in rats treated with all combinations of Cd
and PCBs if compared with groups treated with Cd only, while only highest dose of Cd combined with different doses of PCBs
resulted in higher creatinine levels and relative kidney weight. Synergistic interactions between Cd and PCBs have been proven
for urea levels indicating more profound nephrotoxic potency of this mixture when compared to Cd induced effect on kidneys.
Biography
Vesna Matovic has completed her PhD at Faculty of Pharmacy, University of Belgrade, Serbia. She is Head of Department of Toxicology “Akademik Danilo
Soldatovic” and President of Serbian Society of Toxicology. She has published more than 250 papers in reputed journals and has been serving as an Editorial
Board Member and reviewer.