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Volume 6, Issue 6(Suppl) J Clin Toxicol 2016
ISSN: 2161-0495, JCT an open access journal
Page 57
Notes:
Euro Toxicology 2016
October 24-26, 2016
conferenceseries.com
Toxicology & Applied Pharmacology
October 24-26, 2016 Rome, Italy
7th Euro-Global Summit on
Guidance on the selection of cohorts for extended one-generation reproduction toxicity study
(OECD 443)
Alan Poole
European Centre for Ecotoxicology & Toxicology of Chemicals, Belgium
The extended one-generation reproduction toxicity study (EOGRTS; OECD test guideline 433) is a new and technically
complex design to evaluate the putative effects of chemicals on fertility and development, including effects upon the
developing nervous and immune systems. In addition to offering a more comprehensive assessment of developmental toxicity,
the EOGRTS provides important improvements in animal welfare through reduction and refinement of use of experimental
rodents in a modular study design. The challenge to the practitioner however is to know how the modular aspects of the
study should be triggered on the basis of prior knowledge of a particular chemical, or on earlier findings in the EOGRTS
itself, requirements of specific regulatory frameworks not withstanding. The purpose of this document is to offer guidance on
science-based triggers for these extended evaluations.
Biography
Alan Poole earned his PhD from the University of Surrey and is a Fellow of the Royal College of Pathologists. He worked for the UK Medical Research Council
before moving to Smith Kline and French to lead a team involved in preclinical development of pharmaceuticals. He was later employed by Dow Chemical in
Switzerland where he worked addressing safety of industrial chemicals. He has published widely and is currently the Secretary General of the European Centre for
Ecotoxicology and Toxicology of Chemicals (ECETOC).
Alan Poole, J Clin Toxicol 2016, 6:6(Suppl)