euro-obesity-2016_posters-accepted-abstracts

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Volume 6, Issue 8(Suppl) J Obes Weight Loss Ther 2016
ISSN: 2165-7904 JOWT, an open access journal
Page 45
Notes:
Euro Obesity 2016
October 10-12, 2016
conferenceseries.com
7th Obesity & Endocrinology
Specialists Congress
October 10-12, 2016 Manchester, UK
A synergistic effect of fucus vesiculosus extracts and alginate on inhibition of lipase
Moaz Zulali, Chris Ward and Jeffrey Pearson
New Castle University, UK
Obesity is one of the most important issues in global health. Orlistat is the only approved pharmaceutical treatment for obesity.
However, side effectsmay appear in individuals who useOrlistat such as fecal incontinence, oily spotting, and increased defecation
frequency. Other lipase inhibitors derived from natural products such as seaweed are being investigated. However, their side effects
on lower bowel function are likely to be similar to Orlistat. In order to reduce GI side effects, we are investigating synergistic effects
of fibrous alginate and seaweed extracts. Three types of alginate were added to 3 different f. vesiculosus extracts, and the ability of
the mixtures to inhibit lipase activity was tested. A modification of the method of was used to determine the inhibitory effects of
the mixtures of f. vesiculosus extracts and alginates on lipase activity. This study showed that all fucus vesiculosus extracts tested can
inhibit lipase activity. All the extracts had a similar inhibitory effect on lipase activity. Alginate manugel DMB was the best inhibitor
on lipase activity assay followed by alginate PH157 and LFR5/60, respectively. The results showed that the synergistic effect between
f. vesiculosus extracts and alginates (PH157 and LFR5/60) improved the lipase inhibition. However, the mixtures of f. vesiculosus
extracts and alginate manugel DMB did not show any improvement in lipase inhibition. Further studies need to be carried out in
order to characterize the mechanism of f. vesiculosus extracts and alginate mixtures on lipase activity.
Biography
Moaz Zulali is an MSc Nutritional Science Graduate of Northumbria University in Newcastle upon Tyne. He is a BSc Biology Graduate of College of Education (Scientific
Section) of King Abdulaziz University. He is interested in Physiology and Nutrition Science. Currently, he is studying PhD of Physiology in Institute for Cell and Molecular
Biosciences at Newcastle University.
Moaz Zulali et al., J Obes Weight Loss Ther 2016, 6:8(Suppl)