4 / 24
Page 26
Notes:
conferenceseries
.com
Volume 5, Issue 6(Suppl)
J Infect Dis Ther, an open access journal
ISSN: 2332-0877
Euro Infectious Diseases 2017
September 07-09, 2017
September 07-09, 2017 | Paris, France
Infectious Diseases
6
th
Euro-Global Conference on
Phytotherapy from
Mentha piperita
L. modulates infection during experimental schistosomiasis
Fernanda F Anibal
1
, Karina A Feitosa
1
, Maurício G Zaia
1
, Silmara M Allegretti
2
, Edson G Soares
3
and
Ana Afonso
4
1
Federal University of São Carlos, Brazil
2
UNICAMP, Brazil
3
FMRP-USP, Brazil
4
IHMT, Portugal
S
chistosomiasis is a chronic parasitic disease promoted by the parasite of the genus
Schistosoma
, and Praziquantel (PZQ) is the
only drug recommended by the World Health Organization, but there are reports of resistance, suggesting the importance of
studying new compounds to treat this disease. In this work, we investigate the immunomodulatory and antiparasitic effects of
Mentaliv (Apsen), from
Mentha piperita
L. during murine infection by
S. mansoni
(Sm). Experimental groups: Balb/c females, C,
uninfected, SM, infected without treatment, Mentha 15 (50 mg/kg) infected with Sm (80 cercariae/animal), Mentha 60 (50 mg/kg),
infected and treated daily for 60 days and PZQ, infected and treated with single dose (400 mg/kg) at the 43
rd
day after infection. The
cell profile in the blood and serum IL-4 and IL-10 cytokines were analyzed. And the antiparasitic effect on egg count in the liver,
intestine and granulomas, and comet assay for DNA modifications in worms recovered after treatments. Mentaliv phytotherapy has
immunomodulatory and antiparasitic effects during murine infection of experimental schistosomiasis, by reducing serum levels
of IL-4 and IL-10, and indirectly modulating negatively the blood eosinophils in the Mentha 60 group. In addition, there is an
antiparasitic effect in these animals of the Mentha 60 group where there is a reduction in the number of eggs in the liver, intestine and
in the hepatic granulomas. However, the absence of the genotoxic effect on Sm, suggests that other structures of the parasite other
than DNA are being altered and thus contributing to the reduction of parasitic load. Thus, it is suggested that menthol and menton
may be the main components of
Mentha piperita
L. with antiparasitic effect in this model.
Biography
Fernanda F Anibal has completed her PhD from University of São Paulo, Brazil in Basic and Applied Immunology. She is a Principal Investigator at Laboratory of
Inflammation and Infectious Diseases (Federal University of São Carlos) seeks new tools for the treatment, prevention and diagnostics for infectious diseases.
Currently, they are working with two plants and six enzymes and their effects against Schistosomiasis mansoni, leishmaniasis and toxocariasis, about the treatment
of the infectious diseases. Their group studies effects of plants (extracts) and their isolated fractions to evaluate the anti-parasitic and anti- inflammatory effects and
for infectious disease prevention, moreover have been working on the evaluation of the proteins of the parasite that has been potential to induce immune responses
that decrease the parasite burden.
ffanibal@ufscar.brFernanda F Anibal et al., J Infect Dis Ther 2017, 5:6(Suppl)
DOI: 10.4172/2332-0877-C1-032