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conferenceseries
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Volume 5, Issue 6(Suppl)
J Infect Dis Ther, an open access journal
ISSN: 2332-0877
Euro Infectious Diseases 2017
September 07-09, 2017
September 07-09, 2017 | Paris, France
Infectious Diseases
6
th
Euro-Global Conference on
What is the prevalence of upper respiratory tract pneumococcal carriage in chronically malnourished
children aged from birth to five years?
Holly Smith
Liverpool School of Tropical Medicine and the University of Liverpool, UK
Background and Objectives:
Respiratory-tract infections and invasive disease caused by Streptococcus pneumoniae (Spn)
are a major cause of childhood deaths worldwide. Colonisation of Spn is a prerequisite to pneumococcal disease and carriage
is high in children under 5 years. Chronic malnutrition impairs immune responses, rendering children more susceptible to
infection. This is reflected by higher incidence of disease. As studies have suggested the paradigm of chronic malnutrition
leading to increased rates of Spn carriage, the aim of this systematic review is to determine the prevalence rate of pneumococcal
carriage in the upper respiratory tract of chronically malnourished children under the age of 5 years.
Methods:
A systematic search of the existing literature reporting upper respiratory tract prevalence rate of Spn colonisation
in malnourished children under the age of five, using Medline, PubMed, Web of Science and Scopus, was carried out. An
eligibility criteria was used to include relevant papers.
Findings:
The prevalence rate of Spn colonisation in malnourished children under the age of 5 was high. Prevalence at birth
ranged from 1.0-2.0% and this greatly increases at 2 months to 53.9-80.0%. Carriage remains high from 3 months to 60 months
at 64.1-88.0%. Meta-analysis showed a pooled prevalence of 67.2% in 0-3 months infants (95% CI, 55.6-78.7%), 77.9% in 3-6
months infants (95% CI, 68.1-87.7%) and 77.8% in 6-60 months infants (95% CI, 73.9-81.6%).
Conclusion:
In chronically malnourished children, pneumococcal carriage is frequent. However, as data is limited, further
research is needed to investigate the aetiology and the strength of this association.
h.smith4@liv.ac.ukJ Infect Dis Ther 2017, 5:6(Suppl)
DOI: 10.4172/2332-0877-C1-033