14 / 18
Page 43
Notes:
conferenceseries
.com
Volume 8, Issue 2 (Suppl)
J Biosens Bioelectron, an open access journal
ISSN: 2155-6210
Euro Biosensors 2017
July 10-11, 2017
July 10-11, 2017 Berlin, Germany
7
th
Euro Biosensors
and Bioelectronics Conference
Detection of pH/H
2
O
2
and prostrate/breast cancer biomarker by using nickel-oxide/iridium-oxide sensing
membrane in electrolyte-insulator-semiconductor structure
Siddheswar Maikap
Chang Gung University, Taiwan
Q
uantification of pH/H
2
O
2
attracts a lot of attention due to its importance in chemical industries as well as biomedical diagnostic.
For the detection of pH and H
2
O
2
, using electrolyte-insulator-semiconductor (EIS) is preferred due to label-free detection, easy
fabrication process, and low cost. The NiO
x
based sensor has shown good pH sensitivity of 50.25 mV/pH. X-ray photo-electron
spectroscopy of Ni 2p
3/2
has shown two different oxidation states of NiO
x
membrane and those are Ni
2+
and Ni
3+
having binding energy
854.5 eV and 856.5 eV, respectively. Existence of these two oxidation states resembles the reduction-oxidation (redox) characteristics
of NiO
x
membrane toward the electroactive species like H
2
O
2
. A reference voltage shift of 41 mV is obtained for H
2
O
2
concentration of
10 µM and has shown good linearity up to 100 µM for the first time. In addition, the IrO
x
membrane shows a record pH sensitivity of
150.4 mV/pH for the first time. This IrO
x
sensor demonstrated good catalytic behavior as well as the breast cancer biomarker LOXL2
with a concentration of approximately 150 nM is detected. This IrO
x
nano-net sensor demonstrates good catalytic behavior for H
2
O
2
reduction with a concentration of 100 fM because the oxidation state changes from Ir
3+
to Ir
4+
, whereas a pure SiO
2
membrane could
not sense H
2
O
2
. The oxidation states are confirmed by X-ray photo-electron spectroscopy (XPS). Similarly, prostate cancer is also
detected by using NiO
x
membrane. Therefore, good pH response and redox characteristics of the IrO
x
/NiO
x
sensing membrane allow
it to diagnose human disease in future.
Biography
Siddheswar Maikap has completed PhD in Department of Physics and Meteorology at IIT Kharagpur in February, 2003. He is Professor at Chang Gung University,
Taiwan, since August 2014. He is the holder of three US patents on memory/bio-sensor, eight US/Taiwan patent files, and has more than 100 SCI journal papers,
more than 150 international conference papers, 26 keynote/invited talks, and four best paper awards. His recent research focuses on cross-point resistive switching
memory for high-density memory as well as bio-sensor applications.
sidhu@mail.cgu.edu.twSiddheswar Maikap, J Biosens Bioelectron 2017, 8:2(Suppl)
DOI: 10.4172/2155-6210-C1-033