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Clinical Pharmacology & Biopharmaceutics | ISSN : 2167-065X
Volume 7
September 18-19, 2018 | Amsterdam, Netherlands
6
th
European Biopharma Congress
Euro Biopharma 2018
From traditional materials to modern drug: How Chinese medicines contribute to new drug discovery
Yibin Feng
The University of Hong Kong, China
F
acing complicated diseases and unmet medical needs, drug discovery and development from Chinese medicines should have new
strategy. There are about 25% modern drugs inspired from traditional medicine including Chinese Medicine. The way of drug discovery
and development in past 100 years is from natural resources to chemical synthesis, but no matter whether it is natural compound or
synthesized compound drug discovery and development are more and more difficult. Not only experience in natural materials, but also
wisdom and knowledge in traditional medicine may help form new strategy to discover new drug. It is known that 25% modern drugs were
inspired from traditional medicine. It has been intensively studied a lot about natural resource in terms of chemical and pharmacological
profiles. So far, over 10000 single compounds were isolated from Chinese medicines (Chinese medicinal plants, animal parts and minerals)
among which some have been identified as new drugs such as ephedrine, artemisinin and arsenic trioxide etc., while others are promising
drug candidates suggesting that Chinese medicines are still an important resource for new drug discovery. It is more amazing, if we watch
composite formulae, they are over 100000 in total. Clinically, Chinese medicines mainly use composite formulae to treat various diseases,
especially complicated diseases. Recently, both experimental and clinical studies showed Realgar-indigo naturalis, qili qiangxin capsules
and compound danshen dripping pills are promising formulae for treatment of acute promyelocytic leukemia, chronic heart failure and
coronary heart disease. Actually, Western medicines also often use combination therapy for disease treatment in clinical setting, such
as cancer, hypertension and AIDS etc. To this goal, we developed a comprehensive, dynamic and specific strategy for drug discovery
for cancer and metabolic diseases as one attempt. This presentation will talk about drug discovery from single compounds to multiple
components as drug candidates in Chinese medicine by recent developed technologies.
yfeng@hku.hkClin Pharmacol Biopharm 2018, Volume:7
DOI: 10.4172/2167-065X-C1-029