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Clinical Pharmacology & Biopharmaceutics | ISSN : 2167-065X
Volume 7
September 18-19, 2018 | Amsterdam, Netherlands
6
th
European Biopharma Congress
Euro Biopharma 2018
Modulating drug release from sustained release polyethylene oxides: effect of vitamin E, mannitol and dicalcium
phosphate
Saeed Shojaee, Ali Nokhodchi and Faezeh Majzoubi
Universities of Kent and Greenwich, UK
Introduction & Objective:
Different molecular weight forms of polyethylene oxide can be used successfully in controlled release drug
delivery due to their excellent matrix forming properties. The objective of this study is to investigate the effect of vitamin E succinate and
different fillers on release rate stability of highly soluble drug diltiazem HCl containing polyethylene oxides.
Results & Discussion:
The effect of storage conditions showed that the release rate of the drug was significantly increased from tablets that
were stored for longer periods at 40°C. That is to say, drug release was faster at longer storage times (8>4>2>0 weeks).The increase in drug
release is expected to be due to oxidative degradation primarily in the amorphous region of the polymers that there was significant decrease
in the drug release rate of the formulations that contained mannitol and DCP. The results in indicated the use of vitamin E stabilized PEO
and decreased the rapid drug release occurring as a result of the storage time (2, 4, 8 weeks) at 40°C. The reason behind this phenomenon
could be when vitamin E was dispersed in the PEO containing drug; it delayed the penetration of oxygen into the PEO matrix during the
storage time.
Conclusion:
The results indicated that PEO can successfully be used in controlled release drug delivery; vitamin E and fillers stabilized
drug release from aged matrices containing PEO.
Shojaee41@yahoo.comClin Pharmacol Biopharm 2018, Volume:7
DOI: 10.4172/2167-065X-C1-029