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Clinical Pharmacology & Biopharmaceutics | ISSN : 2167-065X
Volume 7
September 18-19, 2018 | Amsterdam, Netherlands
6
th
European Biopharma Congress
Euro Biopharma 2018
Fluorescent and T1 MRI active multilayer nanoparticle for imaging and targeting cellular delivery
Oara Neumann
Rice University, USA
M
ultifunctional plasmonic nanostructures have enormous potential in the treatment of solid tumors; however, tracking particles with
drug cargo and triggering the release of the cargo in mapped tumors is still impossible. To overcome this challenge we have developed
an MRI and fluorescent active nanostructure nanomatryoshka. This new nanostructure with IR plasmonic signatures is composed of a 50
nmAu core surrounded by dye molecules and Gd (III)-DOTA chelate doped SiO
2
inner-shell and an outer Au shell. The experimental result
demonstrates an enhanced T
1
relaxation (r
1
~24 mM
-1
s
-1
at 4.7 T) compared to the clinical Gd (III)-DOTA chelating agents (r
1
~4 mM
-1
s
-1
).
Further, this design preserves the fluorescence signal (65%) after 24 hours of exposure, leading to enhanced fluorescence photostability
(23x). This dual-imaging functionality nanosystem increases MRI sensitivity by concentrating Gd (III) ions into the Gd-NMs, reduces
the potential toxicity of Gd (III) ions and dye molecules by preventing their release
in vivo
through the outer Au shell protection, and the
terminal gold layer surface can then be functionalized to increase cellular uptake, circulation time, or thermal drug-release properties.
Oara.Neumann@rice.eduClin Pharmacol Biopharm 2018, Volume:7
DOI: 10.4172/2167-065X-C1-029