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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Sleep macrostructure in Lennox-Gastaut Syndrome: A polysomnographic case-control study
Marco Carotenuto
1
, Francesco Precenzano
1
, Ilaria Bitetti
1
and
Michele Roccella
2
1
University of Campania "Luigi Vanvitelli", Italy
2
University of Palermo, Italy
L
ennox-Gastaut syndrome (LGS) is an epileptic encephalopathy defined by a triad of multiple drug-resistant
seizure types, a specific EEG pattern showing bursts of slow spike-wave complexes or generalized paroxysmal fast
activity, and intellectual disability. The prevalence of LGS is estimated between 1 and 2% of all patients with epilepsy.
The relationship between sleep disturbances and refractory epileptic encephalopathies (EEs) are still scarce. The aim
was to assess, by means of nocturnal polysomnography, if children with LGS present with objective alterations in
sleep macrostructure. 33 children with LGS (21 males; mean age: 7.9 ± 1.4 years) and 33 healthy controls (22 males;
mean age: 8.1 ± 1.1 years) underwent an overnight full polysomnography (PSG). Relative to controls, children with
LGS showed a significant reduction in all PSG parameters related to sleep duration time in bed (TIB-min; p< 0.001),
total sleep time (TST-min; p<0.001), and sleep percentage (SPT-min; p <0.001), as well as significantly higher REM
latency (FRL-min p<0.001), rate in stage shifting (p = 0.005), and number of awakenings/hour (p = 0.002). Relative
to controls, children with EEs also showed significant differences in respiratory parameters (AHI/h, p<0.001; ODI/h,
p<0.001; SpO2%, p<0.001; SpO2 nadir%, p<0.001) and a higher rate of periodic limb movements with an index per
hour >5 (PLMs%, p<0.001). Our findings suggest that sleep evaluation could be consideredmandatory in children
with Lennox-Gastaut syndrome in order to improve the clinical management and the therapeutic strategies.
Biography
Marco Carotenuto completed his Degree in Medicine and Surgery in 2000 and Specialist degree in Child Adolescent Neuropsychiatry in 2005. In 2008, he
completed Doctorate in Behavioural and Learning Disorders Sciences. From 2008 to 2011, he was a Junior Researcher and from 2011 to 2017, he was a Senior
Researcher in Child and Adolescent Neuropsychiatry and. In December 2017, he became Associate Professor at Università della Campania Luigi Vanvitelli. He
is the Chief of the Clinic of Child Neuropsychiatry and his research and clinical areas of interest have been focused on pediatric sleep disorders, pediatric primary
headaches, and pediatric rehabilitation.
Marco Carotenuto et al., J Alzheimers Dis Parkinsonism 2019, Volume 09