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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Antiepileptic activity of Nelumbo nucifera fruit
Muhammad Ali Rajput
Liaquat National Hospital Medical College Karachi, Pakistan
E
pilepsy is the most commonly encountered neurological disorder affecting around 70 million people worldwide,
out of which approximately 80% belongs to developing countries. Several shortcomings appeared with the use
of conventional antiepileptic agents like, inadequate seizure control, side effects and cost which limit their use. Thus
extensive studies are necessary to investigate the pharmacological effects of plants, which would facilitate discovery
of novel drugs from herbal source permitting their use to benefit mankind. Hence current study was focused to
evaluate the antiepileptic potential of Nelumbo nucifera fruit (NNF) in order to ascertain its therapeutic potential.
Anti-epileptic activity was assessed using strychnine induced seizure model in 35 male Wister rats divided in five
groups i.e. control, reference and 3 test groups. Each group was composed of 7 animals and was given 2% gum
tragacanth (control), diazepam 1 mg/kg PO (reference) and NNF 50, 100 and 200 mg/kg PO (test) OD for 15 days.
NNF extract at 200 mg/kg exhibited extremely noteworthy delay in the inception of convulsions as compared
to control however duration of convulsions was increased significantly but intensity of convulsions was reduced
resulting in better survival rate i.e. 42.85% which was comparable to diazepam. Therefore it can be concluded that
NNF may be valuable in managing epilepsy but further preclinical and clinical trials are required to confirm these
findings.
J Alzheimers Dis Parkinsonism 2019, Volume 09