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Volume 09
Journal of Alzheimers Disease & Parkinsonism
ISSN: 2161-0460
Epilepsy 2019
Parkinsons Congress 2019
August 29-31, 2019
JOINT EVENT
conferenceseries
.com
August 29-31, 2019 Vienna, Austria
&
5
th
International Conference on
Epilepsy & Treatment
5
th
World Congress on
Parkinsons & Huntington Disease
Passiflora incarnata mitigates the oxidative stress and neuroinflammation in case of pilocarpine-induced
epilepsy model
Abdelaziz S. A. Abuelsaad
Beni-Suef University, Egypt
Background:
Virulent epileptogenic insult is still one of the most life threatening during the clinical consequences
and neurological emergencies of epilepsy. Furthermore, the use of anti-inflammatory drugs during this period is very
controversial. Thus, the present study is designed to delineate the changes in the expression of neurotransmitters,
imbalance in blood electrolytes; oxidative stress, levels pro-/anti-inflammatory cytokines, and after treatment with
of pasipay (Passiflora incarnata).
Methods:
The effect of oral administration of pasipay (P. incarnata) (200 mg/kg body weight) on pilocarpine-
induced seizures was assessment. The correlation between seizure activity and levels of proinflammatory (IL-1, IL-
6, IL-17, TNF- and TGF-) and anti-inflammatory cytokines (IL-10 and IL-13), oxidative stress (lipid peroxidation,
superoxide dismutase, catalase and glutathione reductase), enzymes, monoamines and neurotransmitters e.g Na+-
K+-ATPase; creatinine kinase (CK), acetylcholinesterase, epinephrine and norepinephrine, L-DOPA, serotonin
“(5-HT)”, glutamate, aspartic acid, GABA and glycine; electrolytes e.g. Na+, K+, Ca+2 and Mg+2; and Th1 & Th2
lymophocyte activities (CD4+ and CD8+) were quantified. Whether P. incarnata supplementation modulated these
impairment parameters or not, was also investigated.
Results:
A very significant amelioration in amino acids, neurotransmitters, blood electrolytes, antioxidants and
inflammatory cytokines in epileptic-treated rats with pasipay (P. incarnata). The multifunctional activities of P.
incarnata as antioxidant, anti-inflammatory and antiepileptic modulator drug were discussed and correlated with
other investigations.
Conclusion:
In conclusion, natural products like pasipay (P. incarnata) could be combined with the highly repetitive
drugs to minimize or prevent the side effects of antiepileptic drugs (AED). Moreover, present study supports further
attempts to abrogate the neural dysfunction via antioxidant and anti-inflammatory cascade activities using P.
incarnata.
Key Words:
Epilepsy – Pilocarpine – Passiflora – inflammation – Cytokines – Neurotransmitters – oxidative stress.
J Alzheimers Dis Parkinsonism 2019, Volume 09