3 / 18
Page 25
Notes:
conferenceseries
.com
Volume 8
Journal of Environmental & Analytical Toxicology
EnviTox Summit 2018
September 17-18, 2018
September 17-18, 2018 Singapore
18
th
Global Summit on
Environmental Toxicology and Pharmacology
Soledad Chamorro et al., J Environ Anal Toxicol 2018, Volume 8
DOI: 10.4172/2161-0525-C2-015
Toxicological assessment of Acetaminophen, Ibuprofen and Furosemide pharmaceuticals on
aquatic organisms
Soledad Chamorro
1
, Margarita Lopéz
1
, Gester Gutiérrez
2
and Cristina A Villamar
3
1
Universidad Santo Tomás, Colombia
2
Universidad de Concepción, Chile
3
Universidad de Santiago de Chile, Chile
A
cetaminophen, ibuprofen and furosemide effect are inside of 140 pharmaceutical products detected in water resources. The
main route of entry to aquatic environments of these compounds is from municipal wastewater to concentrations under
3 μg/L. Recalcitrance to biodegradation in wastewater treatment plant and their chemical properties (solubility, coefficient
octanol-water) favored the presence and potential toxicological effect on organisms of aquatic environments. Therefore, the
aim of this work was to assessment of theses pharmaceutical products on freshwater organism
Daphnia magna
and
Selenastrum
capricornutum
, as well as marine organisms such us
Artemia salina
and
Arbacia spatuligera
. The methodology was based on
acute/chronic bioassays on
D. magna
(24-48 hours -LC
50
, reproductive effects),
S. capricornutum
(72 hours-LC
50
),
A. salina
(48
hours-LC
50
) and
A. spatuligera
(reproductive effects). Pharmaceutical concentrations were tested in values from 1.0 to 260.0
mg/L for acetaminophen and ibuprofen, while concentrations from 1.0 to 64.0 mg/L for furosemide. Results demonstrate
the acute toxicity from acetaminophen reached values between 0.26 mg/L for
S. capricornutum
and 21.40 mg/L
D. magna
.
Furosemide showed acute toxicity of 37.01 mg/L for
A. salina
and 62.31 mg/L for
D. magna
. Finally, ibuprofen reached acute
toxicity values under 0.01 mg/L and 78.11 mg/L for
S. capricornutum
and
D. magna
respectively. Chronic effects related with
reproduction on
D. magna
showed values of media effective concentration (CE
50
) of 15 mg/L for furosemide and 5 mg/L for
ibuprofen. Therefore, toxicity effects on aquatic organisms of these pharmaceutical products depend on tropic level evaluated,
being primary producers (
S. capricornutum
) more sensible than primary consumers (
D. magna
). Marine organisms (
A. salina
)
are more resistant than freshwater organism (
D. magna
). Pharmaceutical products as acetaminophen, ibuprofen evidenced
more toxicity than diuretics drug. Reproductive effects on
A. spatuligera
evidence that ibuprofen and acetaminophen (CE
50
:
0.001 and 0.003 mg/L), respectively is more toxic that furosemide (CE
50
: 0.36 mg/L).
Biography
Soledad Chamorro has her expertise in Toxicology Evaluation (lethal, sublethal, chronic and metabolic) trough bio-indicators and biomarkers as algae,
microcrustacean and fish.
schamorro@santotomas.cl