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.com
Volume 9
Journal of Nutrition & Food Sciences
ISSN: 2155-9600
Clinical Nutrition 2019
March 04-06, 2019
March 04-06, 2019 | Barcelona, Spain
24
th
International Conference on
Clinical Nutrition
The effects of kombucha tea on intestinal integrity in mice
Elaheh Mahmoudi
Alborz University of Medical Sciences, Iran
Z
onula Occludens (ZO) proteins (ZO-1 and ZO-2) are important intracellular Tight Junction (TJ) proteins which
link the cell cytoskeleton to the transmembrane TJ proteins. Destruction of TJ which is called the leaky gut
syndrome attributed to the cause of many autoimmune and inflammatory diseases such as Inflammatory Bowel
Disease (IBD). So, reducing intestinal permeability is the goal of therapeutic approaches. Healing effect of Kombucha
Tea (KT) on the gastrointestinal system particularly its extraordinary effect on the healing of intestinal ulcer has been
purported traditionally and reported scientifically. To evaluate the therapeutic effect of fKT on leaky gut syndrome,
fKT was administered to mice colitis model. The model was set up by administration of 3.5% (w/v) dextran sodium
sulfate salt for seven days and then fKT was administered for the next 14 days. Our results showed, fKT could
ameliorate the disease symptoms of DSS-induced colitis, including body weight loss, bleeding, diarrhea, survival rate
and histological injury contains: epithelial defects, crypt atrophy, edema, PMN infiltration and mucosal disruption in
mice. Along with these changes ZO-1 and ZO-2 expression as major constituent of intestinal TJ were also decreased
in mice with colitis and improved by fKT treatment. Such a decrease may explain the defect and less degree of
complexity in the intestinal tight junction during leaky gut phenomenon. Since fKT reduced the symptoms of colitis
in our experimental models, our findings may increase its promising medicinal value in the treatment of human IBD.
e_m592000@yahoo.comJ Nutr Food Sci 2019, Volume 9
DOI: 10.4172/2155-9600-C2-093