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conferenceseries
.com
Volume 2, Issue 3 (Suppl)
Breast Can Curr Res, an open access journal
ISSN: 2572-4118
Breast Cancer 2017
June 15-17, 2017
June 15-17, 2017 London, UK
5
th
World Congress on
Breast Cancer
Exclusive self-destruction of triple negative breast cancer cells
Cohen-Armon
Tel-Aviv University, Israel
A
newly - discovered mechanism involves the modification of specific proteins that affect the construction and stability
of the spindle structure during mitosis. Their exclusive modification in human cancer cells prevented chromosomes
segregation into daughter cells. Modifications of kinesins and NuMA, preventing their normal activity in the spindle of human
cancer cells disrupted chromosomes alignment in the spindle mid-zone. This induces a rapid cell self-destruction while mitosis
is prevented. Thus, the faster the cancer cells proliferate, the more quickly they die. Research was conducted using both cancer
cell cultures and mice transplanted with human cancer cells. Mice transplanted with triple negative breast cancer cells revealed
the arrest of tumor growth by agents causing their exclusive cell-death during mitosis, without affecting normal proliferating
cells.
Biography
Cohen-Armon working in an Academic position at the Tel-Aviv University Life Science, Neurobiochemistry and Faculty of Medicine, Dept. of Physiology and
Pharmacology and the Sagol School of Neuroscience . In 2001, she was appointed as visiting researcher in Columbia University, New York. She conferred with
Human Frontiers award. She has published more than 30 papers in well reputed and high impact factor journals since 2000. Her research was supported by
Novartis and the active molecule is prepared for use against triple negative breast cancers. She is an academic editor for several journals. Her interest lies in Signal
transduction and Epigenetic mechanisms, protein modifications, drug discovery.
marmon@post.tau.ac.ilCohen-Armon, Breast Can Curr Res 2017, 2:3(Suppl)
DOI: 10.4172/2572-4118-C1-005