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Volume 2, Issue 3 (Suppl)

Breast Can Curr Res, an open access journal

ISSN: 2572-4118

Breast Cancer 2017

June 15-17, 2017

June 15-17, 2017 London, UK

World Congress on

Breast Cancer

Evaluation of diffusion weighted MR Imaging and 18F-FDG PET for monitoring triple negative

breast cancer response to cisplatin treatment

Nguyen Thu Huong

1, 2

, Hirofumi Hanaoka

, Takahito Nakajima

and

Yoshito Tsushima

Gunma University Graduate School of Medicine, Japan

Bach Mai hospital, Vietnam

Objective:

To evaluate the potential of 18F-FDG PET and diffusion weighted MR Imaging (DWI) in predicting response of

triple negative breast cancer (TNBC) to Cisplatin treatment.

Methods:

Cisplatin (10 mg/kg) was injected one shot intraperitoneally into TNBC tumor bearing mice. Animals were imaged

on PET and MRI scanners dedicated to animal use before treatment (day 0) and days 3 and 7 after treatment. The highest

standardized uptake value (SUVmax) and the average of apparent diffusion coefficient value (ADCmean) were measured.

Results:

We evaluated tumor growth of the non-treated mice (n=8) and treatment mice. Treated mice were divided into the

response group (n=7) and the no response group (n=7) based on whether the tumor growth was similar to or slower than

that of the non-treated mouse. SUVmax value on day 3 and day 7 (SUV3, SUV7) showed significant difference between the

response group and no response group (P<0.05), however, ratio of SUVmax on day 7 to day 0 (SUV7/0) showed no significant

difference between three groups (P>0.05). ADC mean value on day 0 (ADC0) of the response group was significantly lower

than that of the no response group (P<0.01). The ratio of ADC mean on day 7 to day 0 (ADC7/0) showed significant difference

between three groups (P<0.01), and ADC7/0 of the response group were significantly higher than those of control group and

no response group.

Conclusions:

ADC0, ADC7/0 is potential early predictors of response of TNBC to cisplatin treatment..

Biography

MD radiologist in Bach Mai hospital of Vietnam, PhD student in Gunma University of Japan .

Nguyen Thu Huong et al., Breast Can Curr Res 2017, 2:3(Suppl)

DOI: 10.4172/2572-4118-C1-005