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Volume 8, Issue 6 (Suppl) J Bioremediat Biodegrad, an open access journal
ISSN:2155-6199 Biopolymers & Bioplastics 2017
October 19-20, 2017
October 19-20, 2017 San Francisco, USA
7th International Conference and Exhibition on
Biopolymers and Bioplastics
Chitosan-coated nanoliposomes as capsaicin carriers
Inocencio Higuera-Ciapara1, Evelin Martínez Benavidez1, Ketzasmin A. Terron Mejia1, Waldo Argüelles-Monal2, Roberto López-Rendón3 and Francisco M.
Goycoolea4
1 CIATEJ, Mexico
2 CIAD-Mexico
3UAEM, Mexico
4University of Leeds, UK
Transport of hydrophobic drugs in human body presents several complications. One of them is the low drug absorption due to their
low solubility. In order of enhance the biodistribution of these drugs, recent investigations have propose the use of amphiphilic
molecules, such as phospholipids, to synthesize nanoparticles or nanocapsules, given that phospholipids can self-assembly in micellar
or liposomes structures. Thus, they are ideal candidates to function as nanocarriers of hydrophobic drugs. In this work, molecular
simulations of nanoliposomes at the mesoscopic scale are performed. These nanostructures were constituted of lecithin, chitosan and
capsaicin. The stability of the liposome and the efficiency of capsaicin encapsulation, as well as the internal and superficial distribution
of capsaicin and chitosan molecules in the nanoliposome were analyzed. Characterization of the system was done through density
maps in the xy-plane and the potentials of mean force (PMF) for interactions between lecithin-chitosan, lecithin-capsaicin and
capsaicin-chitosan. The molecular simulation showed that chitosan is distributed on the surface of the nanoliposome. It was also
observed that in spite of the fact that the nanoliposome had a diameter approximately of 18 nm, it was stable under a 24 microseconds
window. The sizes obtained experimentally usually are among 100 nm and 200 nm.
Biography
Inocencio Higuera-Ciapara has worked and directed three research centers in México; CIAD, CICY and CIATEJ. His main line of research has dealt with chitin and
chitosan applications in the food and health sectors. His early work dealt with chitin and chitosan extraction from shrimp byproducts and their application in wound
healing. More recently, he has also become interested in the molecular interactions between chitosan and various bioactive compounds. He is currently working on
the chitosan-capsiacin interactions with the aim of developing functional bioconjugates.
Waldo Arguelles-Monal et al., J Bioremediat Biodegrad 2017, 8:6 (Suppl)
DOI: 10.4172/2155-6199-C1-012