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Volume 8
Journal of Biotechnology and Biomaterials
ISSN: 2155-952X
Biomaterials 2018
March 05-06, 2018
March 05-06, 2018 | Berlin, Germany
3
rd
Annual Conference and Expo on
Biomaterials
Weight loss, corrosion resistance and biocompatibility of titaniumoxide coatings onmagnesiumalloys
S E Rodil
1
, P Silva-Bermudez
2
, J Victoria-Hernandez
3
, S Yi3
and
D Letzig
3
1
Universidad Nacional Autónoma de México, México
2
Instituto Nacional de Rehabilitación, México
3
Magnesium Innovation Centre, Germany
T
itanium oxide (TiO
2
) has been recognized as the active layer responsible for the good biocompatibility and osteogenic
properties of the Ti-based medical alloys used for dental and orthopedic applications. Meanwhile, magnesium (Mg) and
its alloys are currently widely researched for orthopedic applications, since their mechanical properties are more adequate to
balance load transfer between bone and implant, but also due to its biodegradability. Extensive mechanical,
in vitro
and
in
vivo
studies have been done to improve the biomedical performance of Mg alloys through alloying, processing conditions and
surface modifications, including coatings deposition. The main purpose of such modifications is to extend the degradation
rate of the alloy in order to match it with bone self-healing time. In this work, we are investigating the use of titanium oxide
coatings deposited by physical vapor deposition techniques on high purity Mg alloys. These TiO
2
coatings have been extensively
evaluated to demonstrate that independent of the substrate into which they are deposited, the coatings have the ability to
promote the differentiation of mesenchymal stem cells into the osteoblast lineage, while improving the corrosion resistance
of the uncoated metallic substrate and inhibiting bacterial adhesion. Here, we present the preliminary results of the corrosion
resistance of the coated Mg-alloys in physiological fluids, their cell biocompatibility and weight loss kinetics.
Recent publications
1. Albrektsson T, Chrcanovic B, Jacobsson M and Wennerberg (2017) Osseointegration of implants: A biological and
clinical overview. JSM Dent Surg. 2(3):1022.
2. Wei-wei Chen, Ze-xinWang, Lei Sun and Sheng Lu (2015) Research of growthmechanismof ceramic coatings fabricated
by micro-arc oxidation on magnesium alloys at high current mode. Journal of Magnesium and Alloys 3(3):253-257.
3. Phaedra Silva Bermudez, Argelia Almaguer Flores, Victor I Garcia, Rene Olivares Navarrete and Sandra E Rodil (2017)
Enhancing the osteoblastic differentiation through nanoscale surface modifications. Journal of Biomedical Materials
Research Part A 105(2):498-509.
4. Argelia Almaguer-Flores, Phaedra Silva-Bermudez, Rey Galicia and Sandra E Rodil (2015) Bacterial adhesion on
amorphous and crystalline metal oxide coatings. Materials Science and Engineering: C 57:88-99.
5. Kannan M B and Raman R K (2009)
In vitro
degradation and mechanical integrity of calcium-containing magnesium
alloys in modified-simulated body fluid. Biomaterials 29(15):2306-14.
Biography
S E Rodil has bachelor and master degrees in physics from the National Autonomous University of Mexico (UNAM) and PhD degree from the University of
Cambridge, UK. Her expertise in the development of surface modifications of metallic implants in order to improve the biological response. She has been particularly
interested in the development of coatings to improve the osseointegration of metallic dental and orthopedic implants, aiming to find a solution that might also
decrease the cost of the implants for their use in third world countries. She is a Professor at the National Autonomous University of Mexico, where she is involved
in research and the preparation of the new generation of materials research students.
srodil@unam.mxS E Rodil et al., J Biotechnol Biomater 2018, Volume 8
DOI: 10.4172/2155-952X-C1-088