biomaterials-2017-posters-accepted-abstracts

14 / 36

Page 68
Notes:
conferenceseries.com
Volume 7, Issue 2 (Suppl) J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal Biomaterials 2017
March 27-28, 2017
2nd Annual Conference and Expo on
March 27-28, 2017 Madrid, Spain
Loredana E Nita et al., J Biotechnol Biomater 2017, 7:2 (Suppl)
Nanostructures based on poly(aspartic acid) and bovine albumin by self-assembling procedure
Loredana E Nita, Aurica P Chiriac, Alina Diaconu, Maria Bercea and Mihai Asandulesa
Petru Poni Institute of Macromolecular Chemistry, Romania
In the last decades, considerable attention has been dedicated to study of interactions between polymer-polymer pair and
interpolymer complexes. In this contest, the self-assembling procedure for preparation of functional nanostructure based on linear
polyampholyte polypeptide, poly(aspartic acid) (PAS) and a globular protein, bovine serum albumin (BSA), have been studied. The
main interest was to identify the formation of an interpenetrated complex between a natural protein and a synthetic polymer in
order to design materials suitable for biomedical applications, such as carriers for drug delivery. From the viscometric investigation
of PAS/BSA/water ternary systems, it was observed that, for x* value near 0.5, the maximum of intermolecular interactions among
the two polymeric partners take place. This statement is sustained by the strong raise of the hydrodynamic radius in the same area of
composition. Dielectric spectroscopy data also provide the higher compatibility of PAS with BSA protein molecules and confirm the
best conditions for a stable interpolymer complex formation by self-assembling at the PAS/BSA molar ratio x* of 0.542 in aqueous
solution. Thus, it is quite important for having desired properties - chemical and biological - the setting and fulfillment of the
conditions for achieving the non-covalent forces to make highly functional nanoscale compounds.
Biography
Loredana E Nita is currently a Senior Researcher at Petru Poni Institute of Macromolecular Chemistry, Romania. She has completed her PhD in Chemistry in 2007
at Petru Poni Institute of Macromolecular Chemistry. She has published more than 100 papers in reputed journals and is a member in Editorial Board of some
reputed journals. She participated in more than 15 Romanian Projects and 5 European Projects.