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Bio Summit & Molecular Biology 2016
October 10-12, 2016
Volume 6, Issue 6(Suppl)
J Biotechnol Biomater
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries
.com
October 10-12, 2016 Dubai, UAE
2
nd
World Congress on
Bio Summit & Molecular Biology Expo
Timothy Auta, J Biotechnol Biomater 2016, 6:6(Suppl)
http://dx.doi.org/10.4172/2155-952X.C1.061Reproductive toxicity of aqueous wood-ash extract of
Parkia biglobosa
on male Swiss albino mice
Timothy Auta
Federal University Dutsinma, Nigeria
T
he use of wood-ash extracts, including that of
Parkia biglobosa
as food additives and for medicinal purposes by Gbagyi,
Koro, Ebira and other ethnic groups in the Middle-Belt Region of Nigeria, without knowledge of its possible reproductive
toxicity has been an age long practice. This study thus investigated the toxicity of aqueous wood-ash extracts of
P. biglobosa
on
male reproductive ability, using mice as models. Aqueous extraction of the wood ash of
P. biglobosa
was performed using the
traditional percolation method. Four different dose levels of 0, 5, 50 and 100 mg/kg body weight were administered to 20 male
mice (five per group) for seven days, which were sacrificed 35 days thereafter. Gonadosomatic index, sperm motility, sperm
count, sperm morphology, serum follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone assay and
histopathology of testes were carried out using standard methods. Data were analyzed using descriptive statistics and ANOVA,
considered significant at P<0.05.Though no significant toxic effect on testicular weight, FSH, LH and testosterone was recorded,
sperm motility, live/dead sperm and sperm count decreased significantly with significant increase of abnormal sperm cells
when compared to control. Dose dependent depletion of spermatogenic cells were recorded in the testes. Aqueous wood-
ash extract of
P. biglobosa
had damaging effects on sperm cells and testicular tissues, which could compromise reproductive
potentials.
Biography
Timothy Auta is currently a Doctoral degree candidate in University of Ibadan, Nigeria, where he has obtained his Master’s degree in 2011. He is a young Faculty
Member at Federal University Dutsinma, Katsina State, Nigeria and teaches Biology. He has published 13 papers in reputed journals and presented several papers
at different academic conferences/meetings.
autatimz@gmail.com