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conferenceseries.com
Volume 08 Journal of Alzheimers Disease & Parkinsonism Alzheimer's Congress 2018
May 30-31, 2018
May 30-31, 2018 Osaka, Japan
10th World Congress on
Alzheimer's Disease & Dementia
Accelerated brain aging with relevance to type 3 diabetes and alzheimer’s disease
Ian James Martins
Edith Cowan University, Australia
The main constituent of plaques in the brain of Alzheimer’s Disease (AD) individuals namely Amyloid beta (Aβ) is a
proteolytic product of a larger protein the Amyloid Precursor Protein (APP) protein. Carriers of the apo E4 allele are
at greater risk of developing AD with increased deposition of amyloid-beta plaques in western countries. Protein and Aβ
homeostasis is now crucial to the lifespan of organisms and is an important feature that determines the aging process in
obesity, diabetes and neurodegenerative diseases. The scientific understanding of the maintenance of peripheral blood plasma
Aβ and caffeine metabolism has now become essential to prevent neurodegeneration that is linked to type-3 diabetes. The
concentration of Aβ within the brain is determined by hepatic Aβ clearance and interest in the liver has increased markedly
since in western countries the incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) and insulin resistance has reached
approx. 20% of the developed world. Induction of type-3 diabetes is related to delayed hepatic caffeine metabolism (NAFLD)
with circadian dysynchrony (type-3 diabetes) connected to defective peripheral hepatic caffeine and Aβ metabolism. Healthy
diets stabilize type-3 diabetes and maintain the circadian rhythm with relevance to brain insulin resistance and alzheimer’s
disease.
Biography
Ian James Martins is an Editor and Reveiwer for Open Acess Pub/MDPI journals. He has appointed as the Chief Editor for International Journal of Diabetes
Research (2014-2018); Research and Reviews: Neuroscience (2016-2018) and Journal of Diabetes and Clinical Studies (2017-2018); Scientist for Science
Advisory Board (USA) and Academic with He also has Lifetime Membership by International Agency for Standards and Ratings as Fellow; Winner
of World Academic Championship-2017 in Diabetes and Medical Science (Nutrition).
Ian James Martins, J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C4-046