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Volume 08
Journal of Alzheimers Disease & Parkinsonism
Alzheimer's Congress 2018
May 30-31, 2018
May 30-31, 2018 Osaka, Japan
10
th
World Congress on
Alzheimer's Disease & Dementia
Tumor microenvironment associated immune suppression mediated disease progression
Yi Zhang
The First Affiliate Hospital of Zhengzhou University, China
T
umor microenvironment consists a lot of various cell types and plays a key role for tumor survival.These different cells, such
as Myeloid-Derived Suppressor Cells (MDSCs), Tumor-Associated Macrophages (TAMs), Cancer-Associated Fibroblasts
(CAFs), express different function-associated molecules which are involving in mediating tumor progression. CD39/CD73-
adenosine pathway has been recently defined as an important tumor-induced immunosuppressive mechanism. We here
documented a fraction of CD11b+CD33+ MDSCs in peripheral blood and tumor tissues from Non-Small Cell Lung cancer
(NSCLC) patients expressed surface ectonucleotidase CD39 and CD73. Tumor TGF-β stimulated CD39 and CD73 expression,
thereby inhibited T cell and NK cell activity and protected tumor cells from the cytotoxic effect of chemotherapy through
ectonucleotidase activity. Moreover, CD39+CD73+ MDSCs expressed higher levels of typical MDSC-associated suppressive
factors and were significantly associated with disease progression and the poor response to chemotherapy. Our further studies
for the reduction of CD39 and CD73 expression by Metformin could block the suppressive function. CD39 and CD73 on
MDSCs, therefore, link their immunosuppressive and chemo-protective effects to cancer progression, providing novel targets
for chemo-immunotherapeutic intervention.
yizhang@zzu.edu.cnJ Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C4-046