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conferenceseries
.com
Volume 08
Journal of Alzheimers Disease & Parkinsonism
Alzheimer's Congress 2018
May 30-31, 2018
May 30-31, 2018 Osaka, Japan
10
th
World Congress on
Alzheimer's Disease & Dementia
Chronic microvascular ischemia is associated with cerebral amyloid burden in patients with cognitive
impairment
Hae Won Kim
1
, Hyon-Ah Yi
1
, Kyoung Sook Won
1
and Hyuk Won Chang
2
1
Keimyung University Dongsan Medical Center, Republic of Korea
2
Semyung Radiology Clinic, Republic of Korea
Background & Purpose:
White Matter Lesions (WML), detected as hyperintensities on T2-weighted magnetic resonance
imaging, represent chronic microvascular ischemia in the brain and are considered potential risk factors for memory and
cognitive impairment in the elderly. The purpose of this study is to evaluate the association between WML and the cerebral
β-Amyloid (Aβ) burden in patients with cognitive impairment.
Method:
19, 30 and 34 patients with subjective cognitive impairment, mild cognitive impairment and alzheimer’s disease,
respectively, who underwent brain MRI and F-18 florbetaben PET, were included. The Fazekas scale was used to quantify
WML on brain T2-weighted images. The cerebral Aβ burden was quantitatively estimated using volume-of-interest analysis.
The difference in Fazekas scale was evaluated between the Aβ positive and negative groups. The relationship between the
Fazekas scale and the cerebral Aβ burden was evaluated using linear regression analysis after adjustment for age and sex.
Result:
There were no differences in age and sex among the patients with subjective cognitive impairment, mild cognitive
impairment and alzheimer’s disease. In the overall cohort and mild cognitive impairment group, Aβ positive patients exhibited
significantly higher Fazekas scale compared with Aβ negative patients (0.8 vs. 1.3; P=0.024 and 0.5 vs. 1.4; P=0.022). In addition,
the cerebral Aβ burden was positively correlated with the Fazekas scale (β=0.299; P=0.006 and β=0.517; P=0.003).
Conclusion:
WML are associated with the cerebral Aβ burden in patients with cognitive impairment. This suggests that
chronic microvascular ischemia contributes to the development of alzheimer’s disease.
Biography
Hae Won Kim is a Specialist in the Department of Nuclear Medicine at Keimyung University Dongsan Medical Center, Republic of Korea.
hwkim.nm@gmail.comHae Won Kim
et.al., J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C4-046