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Volume 08
Journal of Alzheimers Disease & Parkinsonism
Alzheimer's Congress 2018
May 30-31, 2018
May 30-31, 2018 Osaka, Japan
10
th
World Congress on
Alzheimer's Disease & Dementia
J Alzheimers Dis Parkinsonism 2018, Volume 8
DOI: 10.4172/2161-0460-C4-046
Orthosiphon stamineus improves cognitive functions after ICV streptozotocin insult in alzheimer’s
disease model
Thaarvena Retinasamy
Monash University Malaysia Campus, Malaysia
A
lzheimer’s disease is a chronic neurodegenerative disease that causes cognitive impairment like learning and memory.
Orthosiphon stamineus
(OS) is a medicinal herb that has been reported to exert various pharmacological activities. The
objective of this study was to evaluate whether this Malaysian plant extract can reverse Streptozotocin (STZ) induced cognitive
dysfunction in experimental animals. Rats were subjected to Intra Cerebro Ventricular (ICV) injections of STZ (3 mg/kg)
bilaterally. The STZ-injected rats received oral treatment of OS (50,100 and 200 mg/kg) one day after the surgery, for 7 days
before being subjected to behavioral analysis. The learning and memory performance was assessed using passive avoidance and
elevated plus maze tests. It was found that the OS administration significantly attenuated learning and memory impairment
induced by STZ-injection. The hippocampal tissues were extracted for gene expression analysis, known to be modulated in AD
condition. All the three doses demonstrated effectiveness against Scopolamine-induced cognitive impairment when compared
to the negative control group. Therefore, these results demonstrate the effectiveness of OS in averting cognitive deficits could
serve as a potential therapeutic option for the treatment of neurodegenerative diseases like AD.
thaarvena@gmail.com