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.com
Volume 8, Issue 3(Suppl)
J Allergy Ther, an open access journal
ISSN: 2155-6121
Allergy-Clinical Immunology 2017
September 07-08, 2017
September 07-08, 2017 | Edinburgh, Scotland
ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
11
th
International Conference on
Clinical picture, diagnostics and condition of the immune system in patients with reactive arthritis
against the background of Epstein-Barr virus infection
Marta Lomikovska
Danylo Halytsky Lviv National Medical University, Ukraine
Introduction & Aim:
The problem of reactive arthritis (ReA) is related to its prevalence, diagnostic difficulties, involvement of
many organs and systems in the pathological process, insufficiently effective treatment. Aim of this study is to study the clinical
and immunological features of the course and diagnostics of ReA against the background of Epstein-Barr virus infection.
Materials & Methods:
24 patients with clinical manifestations of arthritis have been examined. General laboratory,
immunological, serological and molecular genetic studies to determine EBV-infection has been conducted for the patients.
Results & Discussion:
Clinically, all patients experienced arthralgic. In addition, six (25%) people have been diagnosed with
long-lasting subfertility, 16 (66.67%) - chronic fatigue syndrome, seven (29.1%) - respiratory immunodeficiency. According to
the results of research, five (20.8%) patients had positive rheumatoid factor, six (25.0%) - increased ESR, 10 (41.7%) - increased
AS (L) O level, and five (20.8%) - increased concentrations of CRP. High titers of specific antibodies of class IgM, IgG to capsid
and nuclear antigens ЕВV and ЕВV-DNA have been found in saliva, mucous membrane scraping and blood of the patients by
the method of polymerase chain reaction. The immunogram analysis more often pointed to the presence of immunodeficiency
by the combined lymphocytic-phagocytic type in 18 (75%) of the examined, among whom lymphocytosis was observed in
seven (29.1%) patients. The increased number of natural killer cells was determined in nine (37.5%) patients, and in 13 (54.1%)
- changes of CD8+-lymphocytes. 13 (40.6%) patients had increased levels of T-helper cells which can be interpreted as a
prerequisite for the formation of auto aggression. Patients were treated with antiviral, immunotropic, symptomatic therapy,
specific immunoglobulins.
Conclusions:
ReA of EBV-origin was most often found in women (70.8%) aged 18-35, and was characterized by an increase
rheumatoid factor (20.8%), CRP (20.8%), AS (L) O (41.7%), ESR (25%) against the background of the absence of autoantibodies
specific for rheumatoid arthritis.
Biography
Marta Lomikovska completed her Medical Studies at Danylo Halytsky Lviv National Medical University and internship on Speciality Therapy at Lviv National Medical
University and Lviv Regional Clinical Hospital. From 2003 to 2008, she worked at the Sokilnyky Medical Clinic as a Therapist. From 2011 till 2013, she is working
in Clinical Immunology and Allergology Department at Lviv National Medical University. From 2014 and till now, she is also working as Assistant Professor in the
same department. She is an author of 15 scientific publications in national and international journals.
ydmarta79@gmail.comMarta Lomikovska, J Allergy Ther 2017, 8:3(Suppl)
DOI: 10.4172/2155-6121-C1-006