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conferenceseries
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Volume 8, Issue 3(Suppl)
J Allergy Ther, an open access journal
ISSN: 2155-6121
Allergy-Clinical Immunology 2017
September 07-08, 2017
September 07-08, 2017 | Edinburgh, Scotland
ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
11
th
International Conference on
Decrypt the link of the ongoing leak:Acase of idiopathic systemic capillary leak syndrome (Clarkson’s
disease): A case report
Ryan Aliñab, Mary Anne Cruz
and
Rosa Ong
Chinese General Hospital and Medical Center Manila, Philippines
Introduction:
Idiopathic systemic capillary leak syndrome (ISCLS) or Clarkson’s disease is an extremely rare and fatal condition
characterized by episodic attacks of capillary leakage of plasma from the intravascular to the interstitial space resulting in
hypotension, hemoconcentration, and hypoalbuminemia. If not diagnosed early, it has a high morbidity and mortality rate.
Treatment is supportive, focusing on aggressive but cautious fluid resuscitation together with pharmacologic treatment to
control capillary leakage. Each attack varies in severity and can be life features threatening due possible organ failure secondary
to poor perfusion.
Aim:
This study aims to raise awareness of the main presentation of ISCLS, to explain the possible pathophysiology, clinical
course of the disease, to differentiate with other causes of distributive shock and to present the latest recommendations on
treatment and prevention based on limited evidences available.
Case Presentation:
Our case is a 38 year old male who initially experienced flu-like symptoms such as body malaise, headache
and generalized weakness. He was previously treated as a case of community-acquired pneumonia, high risk, admitted at
intensive care unit. He claimed to have a history of allergy to seafood and medications such as paracetamol and antibiotics.
In the emergency room, patient was hypotensive and was managed as a case of anaphylactic shock. He was hydrated, started
on inotropic agents and corticosteroid. Work-up tests revealed severe hemoconcentration, hypoalbuminemia, metabolic
acidosis, and hyperkalemia. No focus of infection was documented. He remained stable with negative fluid balance until the
fourth hospital day, when he suddenly developed pulmonary edema. Patient was managed with diuretics, airway support and
inotropics. Patient condition improved and was discharged on 10th hospital day.
Conclusion:
ISCLS is a rare and fatal disease that has a high mortality if not detected early. Therefore, prompt recognition is
important in the effective management of the disease and its complications.
ryanoalinab@yahoo.comJ Allergy Ther 2017, 8:3(Suppl)
DOI: 10.4172/2155-6121-C1-006