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Volume 8, Issue 3(Suppl) J Allergy Ther, an open access journal
ISSN: 2155-6121 Allergy-Clinical Immunology 2017
September 07-08, 2017
September 07-08, 2017 | Edinburgh, Scotland
ALLERGY, ASTHMA & CLINICAL IMMUNOLOGY
11th International Conference on
Immunomodulatory potency of Sargassum horneri via increasing regulatory T cells and suppressing
the mast cell activation
Areum Kim1, Jinhee Cho1, Sumin Shin1, Khinm Herath1, Won Jung Lee1, Ginnae Ahn2, You-Jin Jeon1 and Youngheun Jee 1
1Jeju National University, South Korea
2Chonnam National University, South Korea
Sargassum horneri, a species of brown macro algae, has been reported to have several health promoting effects such as
anti-viral, anti-coagulant effect, and anabolic activity on bone metabolism or higher plumbum absorption. In the present
study, we investigated the immunomodulatory activity of S. horneri using murine splenocytes and bone marrow cultured
mast cells. S. horneri was enzymatically hydrolyzed using the celluclast (SHC). Polyphenol-rich fractions from S. horneri
(SHP) were also used for assessing the anti-allergic activity in BMCMC. SHC induced the proliferation of splenocytes without
cytotoxicity. Treatment with SHC led to a significant increase in the population of CD8+ T cells, CD8+CD25+ regulatory T
cells, and granulocytes. SHC also increased the secretion of IFN-γ. Meanwhile, SHP didn’t show any cytotoxicity in BMCMC
but significantly decreased the release of β-hexosaminidase in stimulated BMCMC. SHP also decreased the mRNA expression
of IL-4, IL-6, IL-13, and TSLP in BMCMC. These findings indicate that S. horneri might modulate the Th2-type immune
responses in immune-mediated disease. Therefore, S. horneri could be an excellent candidate for an anti-allergic agent.
Biography
Areum Kim is a PhD student at Jeju National University, Republic of Korea. He has research interest in Immunology and Radiobiology. He completed his BA in
Nuclear and Energy Engineering at Jeju national University, South Korea from 2009-2013 and; MS in Interdisciplinary Graduate Program in Advanced Convergence
Technology & Science at Jeju National University, Korea from 2013-2016.
Areum Kim et al., J Allergy Ther 2017, 8:3(Suppl)
DOI: 10.4172/2155-6121-C1-006