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Volume 07
Advances in Crop Science and Technology
ISSN: 2329-8863
Agri 2019
August 15-16, 2019
August 15-16, 2019 | Rome, Italy
14
th
International Conference on
Agriculture & Horticulture
The potential anticancer effects of traditional medicinal herbs on oral squamous cell carcinoma
Mahboobeh Razmkhah, Ali Dehghani Nazhvani, Najmeh Sarafraz
and
Fatemeh Askari
Shiraz University of Medical Sciences, Iran
Introduction
: Traditional herbs and spices are widely consumed in the world and contains numerous bioactive
components that are beneficial to consumer health. Documents have endorsed that a diet enriched with fruit,
vegetables and spices can reduce the risk of developing major cancers. Purpose: This study aimed to evaluate the
growth inhibitory activities of four medicinal herbs including saffron, ginger, cinnamon and curcumin on oral
squamous cell carcinoma (OSCC) cell line (KB).
Materials and Method
: Having obtained the aqueous extracts of the four herbs, they were administered on
KB per se and in dual, triple, and quadruple combinations. Their cytotoxic effects were measured in different
concentrations after 24 and 48 hours using MTT assay.
Results
: The minimum and maximum concentrations of extracts were respectively 108 and 217 mg/ml for
curcumin with IC30 of 77 mg/ml, 108 and 270 mg/ml for ginger with IC30 of 58 mg/ml, 2 and 10 mg/ml for
saffron with IC30 of 1.9 mg/ml, and 5 and 40 mg/ml (100% cytotoxicity) for cinnamon with IC30 of 3.3 mg/ml.
The best cytotoxicity of the combination of extracts was seen in cinnamon-saffron after both 24 and 48 hours and
the four herbs combination after 48 hours. Conclusion: The consumption of spices specially saffron and cinnamon
may contribute to the prevention of certain types of cancer including OSCC.
Recent Publications
1. Aghbali A, Hosseini SV, Delazar A, Gharavi NK, Shahneh FZ, Orangi M, et al. (2013) Induction of apoptosis by
grape seed extract (Vitis vinifera) in oral squamous cell carcinoma. Bosn J Basic Med Sci. 13:186-91.
2. Lauritano D, Lucchese A, Contaldo M, Serpico R, Lo ML, Biolcati F, et al. (2016) Oral squamous cell carcinoma:
diagnostic markers and prognostic indicators. Journal of biological regulators and homeostatic agents. 30:169.
3. Buch ZM, Joshi J, Amonkar A, Vaidya AB (2012) Interventional role of Haridra (Curcuma longa Linn) in cancer.
Clinical Cancer Investigation Journal. 1:45.
Mahboobeh Razmkhah et al., Adv Crop Sci Tech 2019, Volume 07
Figure 1. Cytotoxic concentration (mg/ml) of curcumin, saffron, ginger, and
cinnamon on OSCC cell line (KB) after 48 hrs.