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Volume 4, Issue 5(Suppl) J Infect Dis Ther
ISSN: 2332-0877 JIDT, an open access journal
Page 19
Notes:
Euro Infectious Diseases 2016
September 05-06, 2016
conferenceseries.com
Infectious Diseases
September 05-06, 2016 Frankfurt, Germany
3rd Euro-Global Conference on
Prasanth B, J Infect Dis Ther 2016, 4:5(Suppl)
Myocardial dysfunction in patients admitted with dengue fever: Report from a tertiary care center
in North India
Prasanth B
Postgraduate Institute of Medical Education and Research, India
Introduction: Dengue is endemic in more than 125 countries affecting up to 200 million people per year with India having the
maximum burden in Southeast Asia. Myocardial involvement is not an uncommon manifestation in dengue fever and diagnosing
it has always been a challenge to the physicians due to its constellation of clinical features and lack of standard screening methods.
Aim: To study the prevalence of myocardial involvement amongst patients with dengue fever.
Methods: 50 sequential adult patients of dengue fever admitted in our emergency department, PGIMER, Chandigarh, India, were
assessed clinically and classified as dengue fever without warning signs, dengue fever with warning signs and severe dengue as per
WHO 2012 guidelines. They were studied for possible myocardial involvement by means electrocardiography (ECG), point-of-care
testing for cardiac biomarkers (quantitative troponin-I, creatinine kinase-MB Isoform and cardiac myoglobin) and two-dimensional
transthoracic echocardiogram (2D-echo).
Results: We found evidence of myocardial involvement in 26%, 16% and 30% patients based on biomarker testing, 2D-echo and ECG
respectively. On univariate analysis, presence of cardiac symptoms (p=0.009) and presence of shock (p=0.003) showed statistically
significant association with biomarker elevation. However, the three parameters show poor correlation with each other and there is
no single parameter, which is associated with clinical severity.
Conclusion: The prevalence of myocardial involvement in dengue varied from 16-30% in our study in which, compared from prior
studies, we have used ECG, 2D Echo and Cardiac Biomarkers for evaluation in all the patients.
Biography
Prasanth B is currently pursuing Residency at the Department of Internal Medicine, PGIMER, Chandigarh, a premier tertiary care centre in North India. Apart from his
academic activities, he plays guitar and is also interested in adventure sports.