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Volume 4, Issue 5(Suppl) J Infect Dis Ther
ISSN: 2332-0877 JIDT, an open access journal
Page 28
Notes:
Euro Infectious Diseases 2016
September 05-06, 2016
conferenceseries.com
Infectious Diseases
September 05-06, 2016 Frankfurt, Germany
3rd Euro-Global Conference on
Atqah Abdul Wahab et al., J Infect Dis Ther 2016, 4:5(Suppl)
Antibiotic susceptibility pattern of Pseudomonas aeruginosa in cystic fibrosis patients
Atqah Abdul Wahab1, 2, Khalid Zahraldin1, Mazen Sid Ahmed1 and Emad Bashir Ibrahim1
1Hamad Medical Corporation, Qatar
2Weill Cornell Medicine-Qatar, Qatar
Introduction: Pseudomonas aeruginosa (PA) is an important pathogen in patients with cystic fibrosis (CF) and a major cause of
morbidity and mortality. The emergence of multidrug resistant Pseudomonas aeruginosa (MDR-PA) has been an increasing problem
in the care of CF patients. Early detection and appropriate antimicrobial agents may improve outcome in patients with CF.
Objective: To analyze the profile of antimicrobial susceptibility of PA from lower respiratory samples and to describe the frequency
of isolated MDR-PA in CF patients.
Methods: The lower respiratory isolates of PA were obtained from inpatients and outpatients CF clinics from at Hamad Medical
Corporation, in the state of Qatar from October 2014 to September 2015. The antimicrobial susceptibility test of all the isolates was
performed by BD Phoenix automated system according to CLSI guidelines and confirmed by Epsiometer Test (E-test) method.
Results: A total of 61 PA samples were isolated from 30 CF patients with mild to severe lung disease. The mean age of the study
group was 20.56±8.95 years; 25 CF patients (83.3%) with CFTR I234V mutation, other 5 CF patients with other CFTR mutations. All
the isolates were showed highest sensitivity to colostin (100%) followed by piperacillin/tazobactam (90.2%), meropenem (88.5%),
ciprofloxacin (77%), cefepime (70.5%), amikacin (67.2%) and gentamicin (59%). Twelve sputum samples were positive for MDR-
PA from 5 CF patients with moderate to severe lung diseasegiven MDR percentage of 19.7%. The antimicrobial patterns of MDR-
PA isolates showed a highest rate of resistance (100%) towards each gentamycin, amikacin and cefepime, followed by 91.7% to
ciprofloxacin, 75% to tobramycin, 58.3% to meropenem and 50% to pipracilin-tazobactam.
Conclusion: The study results emphasize the emergence of significant resistance in the clinical isolates of P. aeruginosa in CF patients
and need further management of the antibiotic treatment strategy with frequent surveillance is recommended.
Biography
Atqah Abdul Wahab is an Assistant Professor of Clinical Pediatrics at Hamad Medical Corporation, Qatar. He is also associated with Weill Cornell Medicine-Qatar, Qatar.