euro-infectious-diseases-2016_posters-accepted-abstracts

Volume 4, Issue 5(Suppl)

J Infect Dis Ther

ISSN: 2332-0877 JIDT, an open access journal

Page 45

Euro Infectious Diseases 2016

September 05-06, 2016

conferenceseries

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Infectious Diseases

September 05-06, 2016 Frankfurt, Germany

Euro-Global Conference on

Effect of interruption on treatment outcome of drug resistant tuberculosis patients at the Indus Hospital

Rabab Batool, A Malik, H Hussain, Z Barry, S Butt, S Adnan, S Khan and N Salahuddin

The Indus Hospital, Pakistan

he treatment of drug resistant TB (DR TB) is complicated and lengthy. Sometimes patients fail to appear on each month follow

up and the treatment is interrupted. We explored whether the number of months patient has missed follow up during duration

of treatment has any impact on the treatment outcomes. We conducted a retrospective data analysis of the patients enrolled on drug

resistance tuberculosis (DR TB) from 2009 to February, 2016 at the Indus Hospital, Karachi. The number of enrolled patients till

the time of analysis was 895. Still under treatment and transferred out patients were exluded. Hence 623 patients were included in

the analysis. The treatment interruption was defined as the discontinuation of treatment for at least for 30 consecutive days. Median

age of the patients was 27 years (6 months to 85 years) 298 (46%) were females. 489 (79%) were MDR, 31 (5%) were XDR, 36 (6%)

were PDR, 12 (2%) were resistant to Rifampicin only, 55 (9%) were reported to be Rifampicin resistant on GeneXpert. Number

of patients who were declared as treatment failure was 51 (8%), 90 (15%) patients died. Overall success rate was 70% and default

rate was 7%. Number of patients whose treatment was interrupted for at least 30 consecutive days was 110 (18%). Mean number

of days treatment was interrupted was 15 days (0-6 months). Mean number of days treatment was interrupted in the patients who

successfully completed the treatment was 16 days and for those with the poor outcomes it was 24 days. After controlling for age, SLD

history, gender, presence of co morbid diseases and resistance patterns the multivariate logistic regression showed that the number of

months treatment was interrupted was directly associated with poor treatment outcomes (OR 2, 95% CI 1.5-2.2). For this population

overall compliance (% of patients who never miss drugs) is 71%.

J Infect Dis Ther 2016, 4:5(Suppl)

Situation of Crimean Congo hemorrhagic fever in last 15 years in Iran

Sadegh Chinikar

Pasteur Institute of Iran, Iran

rimean Congo Hemorrhagic Fever (CCHF) is a zoonotic viral disease caused by infected tick bite, contact with blood or tissues

of infected livestock and nosocomially. CCHF is a life-threatening virus with a 5-50% fatality rate. CCHF in Iran was reported by

Chumakov in 1970. Since establishment of the Arboviruses and Viral Hemorrhagic Fevers Laboratory in Pasteur Institute of Iran in

2000 till now, 3104 human sera were submitted from different provinces and tested serologically and molecularly. Of 3104, we had 960

confirmed cases and 135 deaths. Males with 747 confirmed cases were the most affected gender. Geographically, Sistanva Baluchistan,

Khorasan and Isfahan provinces had the highest rate of CCHF confirmed cases. Slaughterers (240 cases) and farmers (176 cases)

were the most high-risk occupation. The results of our phylogenetic studies showed that Pakistani, Iraqi and Russian strains are the

circulating in Iran. CCHF is one of the most important viral emerging zoonotic diseases in Iran. CCHF has been mainly seen in

certain professions and regions, as it is mainly related to imported livestock from neighboring countries. Data with respect to the

gender acquired infection shows that CCHF infection in male is more than female, which seems due to male implication in high

risk professions. To establish preventive strategies for CCHF, firstly awareness and training programs for high risk professions and

secondly conducting joint projects with neighboring countries on ticks can play a critical role in the control of disease.