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Volume 6
Journal of Child & Adolescent Behavior
October 01-02, 2018 Osaka, Japan
30
th
World
Psychiatrists and Psychologists Meet
World Psychiatrists 2018
October 01-02, 2018
J Child Adolesc Behav 2018, Volume 6
DOI: 10.4172/2375-4494-C1-006
Assessment of tryptophan metabolism and signs of depression in individuals with carbohydrate
malabsorption
Gernot Kriegshauser
1,2
, Dietmar Enkoa
1,2
, Helga Wagner
3
, Wolfgang Brandmayr
4
, Gabriele Halwachs-Baumann
1
, Wolfgang J Schnedl
5
, Sieglinde Zelzer
2
,
Harald Mangge
2
and Andreas Meinitzer
2
1
Institute of Clinical Chemistry and Laboratory Medicine, General Hospital, Austria
2
Medical University of Graz, Austria
3
Johannes Kepler University Linz, Austria
4
General Hospital, Austria
5
Practice for General Internal Medicine, Austria
Statement of the Problem:
It has been reported that Fructose Mal-Absorption (FMA) is associated with Lower Tryptophan
(TRP) serum concentrations, which may play an essential role in the development of depressive disorders. However, study
designs investigating the serum levels of TRP and TRP metabolites in large patient cohorts with Carbohydrate Malabsorption
(CM) are still lacking. The aim of the present study was to investigate the association between primary adult Lactose
Malabsorption (LMA), FMA, TRP metabolism and the signs of depression in a large cohort of adult patients presenting unspecific
abdominal symptoms.
Methodology & Theoretical Orientation:
A total of 251 patients, who were referred for lactase gene C/T polymorphism
genotyping and fructose hydrogen/methane breath testing, were included. All participants filled out the Beck Depression
Inventory (BDI II). Serum concentrations of TRP, Kynurenine (KYN), Kynuric acid (KYNA) and TRP competing amino acids
(CAAs: Leucine, isoleucine, valine, phenylalanine, tyrosine) were measured by high-pressure liquid-chromatography. Logistic
regression analysis was performed with LMA, FMA and all potential biomarkers of TRP metabolism to assess the effect on
signs of depression, defined as a BDI II score >13.
Findings:
Primary-adult LMA and FMA was detected in 65 (25.90%) and 65 (25.90%) patients, respectively. FMA was
significantly associated with a BDI II score >13, whereas no such relationship was found for LMA. Serum levels of TRP and
TRP metabolites were no predictors of depression.
Conclusion & Significance:
Taken together, in the logistic regression model calculated here, FMA was shown to be associated
with a BDI II score >13, however further prospective longitudinal studies are needed to fully elucidate the relationship between
CM, TRP metabolism and depressive disorders.
gernot.kriegshaeuser@gespag.at