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conferenceseries
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Volume 05
Neonatal and Pediatric Medicine
ISSN: 2572-4983
World Pediatrics 2019
December 04-05, 2019
December 04-05, 2019 | Barcelona, Spain
32
nd
World Pediatrics Conference
Highly sensitive C-reactive protein–an independent determinant of risk of formation of essentsial arterial
hypertension at teenage children
Shamansurova E A, Agzamova Sh A, Akhmedova F M
and
Aliyeva N R
Tashkent Pediatric Medical Institute, Uzbekistan
E
xistence of signs of chronic inflammation at which increase in pro-inflammatory cytokine and as a result-growth
of concentration of the C-reactive protein (CRP) is of the characteristic of the arterial hypertension (AH). CRP and
arterial blood pressure are independent determinants of cardiovascular risk. 78 school students at the age of 14-16 years are
investigated (middle age 14.7±0.2). From them20 children with normal arterial blood pressure (NBP-control group), with
high normal (HNBP) – 20 children (group of comparison), with the labile arterial hypertension (LAH) – 20 and with the
stable arterial hypertension (SAH) – 18 school students (the main groups). Values 0-3.0mg/L are taken for the reference
CRP. The highest CRP level at children from stable AH (1.38±0.4mg/L) with a reliable difference in comparison with
control is established (0.39±0.1mg/L, р <0.05). Increased values of level are noted also at children with LAH (0.9±0.2mg/L,
р <0.05) and HNBP (0.78±0.11mg/L, р <0.05) in relation to parameters of children with NBP. For group of children with
HNAP the CRP level> 1.19mg/L had moderated (% Se=78.6) sensitivity and high specificity (% Sp=86.2). At children
with AH this diagnostic test had higher sensitivity (%Se=87.5), and the specificity was identical (%Sp=86.2). Increase in
indicators AH is associated with increase in the CRP level. Determination of the CRP level at children with AH has high
diagnostic efficiency.
Neonat Pediatr Med 2019, Volume: 05