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conferenceseries.com
Volume 9, Issue 9 (Suppl) J Cancer Sci Ther, an open access journal
ISSN: 1948-5956 World Cancer 2017
October 19-21, 2017
25th WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
New molecular insights of pancreatic ductal adenocarcinoma
Claudio Luchini
University and Hospital Trust of Verona, Italy
Pancreatic ductal adenocarcinoma (PDAC) is a high malignant neoplasm that will represent the second cause for cancer
death in the next 20 years. Recent molecular studies have better clarified its complex genetic landscape. However, many
mechanisms of tumorigenesis of such tumor remain still unclear and of difficult comprehension. The study of peculiar
variants of this tumor type may help in the comprehension of the biology of PDAC. To this aim, we have studied with
immunohistochemistry, FISH (Fluorescent in situ hybridization) analysis and whole-exome sequencing the rare PDAC variant
named undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UCOGC). Firstly, we observed some clinical
and prognostic peculiarities in this PDAC variant. Then we report strikingly molecular similarities of UCOGC to those known
to drive conventional PDAC, including activating mutations in the oncogene KRAS, and inactivating mutations in the tumor
suppressor genes CDKN2A, TP53, and SMAD4. Lastly, we describe a new potential PDAC driver gene which we found in 25%
of UCOGC studied with whole-exome sequencing: the SERPINA3 gene.
Biography
Claudio Luchini is a Surgical Pathologist with expertise in the field of next-generation sequencing and of systematic review with meta-analysis. He has studied at
Verona University, Italy and then Indiana University, USA and Johns Hopkins University as Research Fellow. He has published his important works in Journal of
Clinical Oncology and Cancer Cell. With the tool of meta-analysis, he has highlighted the prognostic role of important morphological and molecular alterations in
cancer. The main goal of his research is to find morphological and molecular markers for early diagnosis of tumors or to better stratify cancer prognosis.
Claudio Luchini, J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-111