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conferenceseries
.com
Volume 9, Issue 9 (Suppl)
J Cancer Sci Ther, an open access journal
ISSN: 1948-5956
World Cancer 2017
October 19-21, 2017
25
th
WORLD CANCER CONFERENCE
October 19-21, 2017 | Rome, Italy
L-Arginine is an Achilles' heel in tumor growth and therapy
Kamran Mansouri
and
Mozhgan Jahani
Kermanshah University of Medical Sciences, Iran
I
n cancer therapy, modulatory effects of L-arginine on various cancers remain a controversial issue. This amino acid is a
substrate for different enzymes and plays a crucial role in regulating multiple metabolic and signaling pathways in both
normal and cancer cells. L-arginine has a complex metabolism and its impacts on the cells are highly linked to the types
and metabolism of them. Previous studies investigating the effects of L-arginine in cancer therapy have provided conflicting
results. While some studies confirm that L-arginine enhances tumor growth, the others introduce L-arginine as an appropriate
candidate for cancer treatment. Contradictory assertions in the case of L-arginine used in cancer therapy suggest that using or
depletion of this amino acid can have different result on the normal and cancer cells. So, this study attempts to reconcile these
opposite notions and to revisit the thesis that L-arginine role in cancer therapy.
Biography
Kamran Mansouri completed his PhD at Tehran University of Medical Sciences, Iran. He is the Head of Department of Molecular Medicine at Kermanshah
University of Medical Sciences, Iran. He has published more than 50 papers in reputed journals.
kmansouri@kums.ac.irKamran Mansouri et al., J Cancer Sci Ther 2017, 9:9(Suppl)
DOI: 10.4172/1948-5956-C1-111