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Journal of Biotechnology & Biomaterials | ISSN: 2155-952X | Volume: 8
3rd World Biotechnology Congress
December 03-04, 2018 Sao Paulo, Brazil
Synthesis structural characterization and antioxidant activity of alkyltrimethylammonium
thiotungstate
J Horta Marron and LB Romero Sanchez
Autonomous University of Baja California, Mexico
An emerging area of research in the field of oxidative stress is the use of inorganic drugs, possessing redox properties, which
act as effective free radical scavengers, a starting point for the development of new therapies to combat oxidative damage.
In this way, it was found in the literature that some ammonium thiosalts, as tetrathiomolybdate (TMA), have anticancer, anti-
angiogenic, antioxidant, anti-inflammatory and have been tried as copper-chelator drugs, including preclinical, animal and
human studies. Although the biological activity of TMA suggests that related inorganic species such as thiotungstate salts
might show analogous behavior, to the author's knowledge, the biological activity of tungstate thiosalts has not been evaluated.
In this work, ammonium thiotungstate (TTA) were synthesized, characterized and their antioxidant activity was evaluated. In
addition, an alkyl chain was incorporated into TTA and the influence of carbon on biological activity was evaluated. TTA was
prepared by direct sulfidation in an aqueous ammonia solution of ammonium metatungstate. The alkyltrimethylammonium
thiotungstate (R-(CH3 )3N) 2 WS4 (R=octyl, dodecyl or hexadecyl) were prepared by means of a simple reaction of ATT with
alkyltrimethylammonium halogens in aqueous solution. The synthesized thiotungstates were characterized using Fourier
transform infrared (FTIR) and ultraviolet (UV) spectroscopic techniques for determining their chemical structures.
Thiotungstate salts antioxidant activity was evaluated using DPPH and ABTS assays. The preliminary results suggest that
the influence of carbon derived from the hydrocarbon chain on the properties of the resulting biomaterials improved their
antioxidant activity.
Biography
J Horta Marron has earned his Bachelor's degree in Industrial Chemistry from the Autonomous University of Baja California and is currently working on research. He
has worked as a quality control technician in several Mexican industries such as petrochemical, alimentary and water waste. He has also collaborated with various
Mexican researchers on projects involving nanotechnology and environmental sciences. Recently, he participated in the Congress of the Faculty of Chemical
Engineering located in the Autonomous University of Yucatán where he presented a ceramic material created from sewage sludge.
J Horta Marron et al., J Biotechnol Biomater 2018, Volume: 8
DOI: 10.4172/2155-952X-C7-107