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Volume 7, Issue 6 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
World Biotechnology 2017
December 04-05, 2017
2
nd
World Biotechnology Congress
December 04-05, 2017 | Sao Paulo, Brazil
Photo-curable natural polymer derivatives for bio-medical application
Tae-Il Son
1
, Jae-Won Kim
1
, Eun-Hye Kim
1
, Seung-Hyun Noh
1
, Shin-Woong Kim
1
and
Yoshihiro Ito
2, 3
1
Chung-Ang University, Republic of Korea
2
RIKEN, Japan
3
Tokyo Institute of Technology, Japan
T
o be biomedical applications, these materials require properties such as biocompatibility, biodegradability, and low-toxicity.
Chitosan is a natural polymer with these properties. In addition, chitosan has anti-bacterial activity. For this reason, chitosan
is suitable as a biomaterial. Growth factors are biomolecules, mainly proteins. Growth factors such as epidermal growth factor,
transforming growth factor-β and bonemorphogenetic protein-2 play an important role in the physiological activity process. Although
growth factors affect their diverse physiological activities in biological processes, their biomedical applications are very limited.
Because growth factors have a half-life that causes to rapidly decrease the physiological activity in the body. Protein immobilization
methods are a way to solve these problems. Various immobilization methods have been developed. However, methods using chemical
agents may form by-products that can potentially cause denaturation of immobilized protein. It is also difficult to immobilize them
in the same chemical method because the residue of each amino acid is different. To solve these problems, our research team have
developed a photo immobilization method for immobilizing proteins using UV and visible light photo-reactive chitosan derivatives.
The additional advantages of this method are relatively simple process, low cost, easy scale-up, and low toxicity. Photo immobilization
methods will be used to immobilize various biomolecules. Our research team report the preparation of photo-reactive chitosan
derivatives that can be used for the immobilization of various biomolecules via photo-immobilization method.
Biography
Tae-Il Son has completed his PhD from Tokyo Institute of Technology, Japan in 1989. Currently, he is a Professor in the Department of Systems Biotechnology, Chung-Ang
University, Republic of Korea and the President of Biomaterial Field in The Korean Society of Industrial and Engineering Chemistry (KSEC). He has published more than
80 papers in reputed journals.
tisohn@cau.ac.krTae-Il Son et al., J Biotechnol Biomater 2017, 7:6 (Suppl)
DOI: 10.4172/2155-952X-C1-085