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Volume 7, Issue 6 (Suppl)
J Biotechnol Biomater, an open access journal
ISSN: 2155-952X
World Biotechnology 2017
December 04-05, 2017
2
nd
World Biotechnology Congress
December 04-05, 2017 | Sao Paulo, Brazil
The probable effect of MT1A (A>G) and MT1A (C>G) SNPs of metallothionein gene on whole blood
mercury levels in iranian populations
Javad Babaei
Valiasr Hospital Research Center, Iran
P
olymorphism in metalloproteins may lead to changes in heavy metal levels in the body. The risk factors of polymorphisms in
heavy metal concentrations, particularly mercury, may be due to several confounding factors including differences in ethnicity
of the analyzes populations, sample size and the type of the studied environment heavy metals to which population are exposed. We
study the effect of MT1A (A>G) and MT1A (C>G) polymorphisms on blood mercury level in Iranian population. 300 non exposure
people to control group and 150 exposure people to case group were used. DNA extraction and PCR-RFLP and DNA sequencing
was done and blood mercury level was measured via AAS technique by DMA-80. Blood mercury concentration in case group was
higher than control group (p value<0.001). There was no significant differences in case and control groups to effect of MT1A (A>G)
and MT1A (C>G) polymorphism on blood mercury levels and P value were 0.69 and 0.44, 0.59 and 0.56 for case and control groups,
respectively. MT1A (A>G) and MT1A (C>G) polymorphism were not associated with increased level of mercury concentration in
Iranian, which needs further investigations. In conclusion, this study suggest that MT1A (A>G) and MT1A (C>G) polymorphisms
are not attractive susceptibility markers for high blood mercury concentration.
Biography
Javad Babaei has completed his PhD from Jondishapur University and PharmD studies from Mashhad University School of Medicine. He is the Director of Valiasr Hospital
Research Center. He has published more than five papers in reputed journals and has been serving as an Editorial Board Member of repute.
dr.babaei1981@yahoo.comJavad Babaei, J Biotechnol Biomater 2017, 7:6 (Suppl)
DOI: 10.4172/2155-952X-C1-085