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Notes:
Volume 7
Traditional and Restorative Medicine & Neuropharmacology 2018 | August 27-29, 2018
Journal of Traditional Medicine & Clinical Naturopathy | ISSN : 2573-4555
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Global Summit on
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10
th
World Congress on
Neuropharmacology
Page 27
August 27-29, 2018 | Paris, France
Chlorogenic acids in combination with cisplatin inhibits the growth and
angiogenesis of breast carcinoma
in vitro
and
in vivo
C
hlorogenic acid was isolated from green coffee beans. It has also been found
in the leaves of Hibiscus sabdariffa and select herbs such as Lonicera japonica
(honeysuckle) and Eucommia ulmoides. Breast cancer is an important malignant disease
among the Chinese. It is one of the most lethal malignant tumors worldwide. In the present
study, we investigated the effects of chlorogenic acids (CGA) and cisplatin (CDDP). on
proliferation, apoptosis, and angiogenesis of HCC
in vitro
and
in vivo
. It was found that
co-treatment of CGA and CDDP could not only induce tumor cells into apoptosis through
activating the mitochondria pathways, but also suppress the angiogenesis in xenograft
animal model. These effects were associated with downregulation of the expression of
MMP2/9, VEGF, and VEGFR-2, up-regulation of P53 signaling. Thus, CGA and CDDP
in combination showed a better anti-tumor effects in breast cells than either CGA or
CDDP presence alone and might represent an effective therapeutic strategy for breast
cancer therapy.
Biography
Ya-Tien Wu is a Registered Professional Nurse and Respiratory Therapist. She is serving as a Professional
Respiratory Therapist in Show Chwan Memorial Hospital for five years. She is participating in science research
in Show Chwan Memorial Hospital Research Center on cancer and herbal therapy.
yaten92@yahoo.com.twYa-Tien Wu et al., J Tradit Med Clin Natur 2018, Volume:7
DOI: 10.4172/2573-4555-C1-002
Ya-Tien Wu
Show Chwan Memorial Hospital, Taiwan
Co-Authors
Wan-Ting Liao
1, 2,
and
Chia-Jung Li
1
1
Show Chwan Memorial Hospital, Taiwan
2
China Medical University, Taiwan