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Volume 3, Issue 1 (Suppl) Toxicol Open Access
ISSN: 2476-2067 TYOA, an open access journal Toxicology Congress 2017
April 13-15, 2017
Page 40
Notes:
conferenceseries.com
April 13-15, 2017 Dubai, UAE
8th World Congress on
Toxicology and Pharmacology
Endocrine disruption and antimicrobials
Endocrine disruptors are hormonally active substances of natural or synthetic origin affecting the endocrine (hormonal)
systems of humans. Such compounds can be found in chemical groups like steroids, cyclic hydrocarbons, phenols,
flavonoids, phtalates, parabens or toxic metals. They are used as antimicrobials, biocides, plasticizers, surfactants, UV filters
or fire retardants. They may be released from consumer products, e.g. cosmetics, toys, food packaging materials, household
products, medical devices and other products of industry or agriculture. In the EU, they are banned for consumer products.
Recently regulated CMR substances from the group of Antimicrobials/Preservatives (biocides) comprise: Chloracetamide
(Reprotox. Cat. 2), Phenol (Mutagenic Cat. 2), Nonylphenol (Reprotox. Cat. 2), Parabens (pentyl-, phenyl-, benzyl- for
absent data on reprotox.), Ketoconazole (Reprotox. Cat. 1B), Boron compounds
(Reprotox. Cat. 1B), Formaldehyde (Carcinogenic Cat. 1B), Polyaminopropyl
Biguanide-PHMB (Mutagenic Cat. 2). Significant reprotoxic effect has been
proved in the past namely for distinct bisphenols (Reprotox. Cat. 2) or phthalates
(Reprotox. Cat 1B or Cat. 2) which were subsequently banned. However, the
production of analogous compounds is increasing underlining the necessity to test
their safety including reprotoxicity. The European Commission's general policy is
the use of alternative toxicological methods in vitro instead of conventional tests on
vertebrates. Available methods in vitro to detect endocrine disruption are: OECD
TG 455/457–Estrogen Receptor Transactivation Test Method, OECD TG 456–
Effects on Steroidogenesis, OECD TG 236–ZFET, zebrafish embryo epigenetic
assay, MCF-7 cell proliferation assay, Xenoscreen YES/YAS yeast assay. Results of
a pilot study to prove applicability of methods in vitro to detect reprotoxicity are
presented.
Biography
Jirova Dagmar, MD, PhD, graduated and received her PhD at the Charles University in Prague. Her professional specialization is in Dermatotoxicology and
Immunotoxicology, focused on safety assessment of cosmetics and other consumer products. She is holding a position of the Head of Centre of Toxicology and
Health Safety at the National Institute of Public Health, Prague, Czech Republic. She is the author of more than 200 publications in scientific journals, proceedings
and monographs, posters or articles and publications for the public. She was the Principal Investigator in number of research projects in the field of alternative
toxicological methods for evaluation of health risks of chemicals and consumer products.
Jirova Dagmar
National Institute of Public Health, Czech Republic
Jirova Dagmar, Toxicol Open Access 2017, 3:1 (Suppl)
Figure 1: OECD TG 455/457-VM7Luc4E2
cell line, kindly provided by Prof. M.
Denison, UCDAVIS, for research purposes.