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conferenceseries.com
Volume 10, Issue 8 (Suppl) J Proteomics Bioinform, an open access journal
ISSN: 0974-276X Structural Biology 2017
September 18-20, 2017
9th International Conference on
Structural Biology
September 18-20, 2017 Zurich, Switzerland
Joachim Krebs, J Proteomics Bioinform 2017, 10:8(Suppl)
DOI: 10.4172/0974-276X-C1-0100
Calcium, calmodulin and the plasma membrane calcium pump
Joachim Krebs
Max Planck Institute for Biophysical Chemistry, Germany
Calcium is the third most abundant metal in nature and a versatile carrier of many signals within and outside the cell. Due
to its peculiar coordination chemistry calcium is highly flexible as a ligand which enables it to regulate many important
aspects of cellular activity. Calcium can fulfill its many distinct functions onsite and out of the cell due to an integrated network
of calcium channels, exchangers and pumps. In this presentation, I will give an overview on our studies of calcium binding
proteins, their interaction with protein targets resulting in specific modulations of protein-protein interactions. This will be
demonstrated by the interaction of the calcium binding protein calmodulin with one of its targets, the plasma membrane
calcium pump, an important regulator of calcium homeostasis of the cell.
Biography
Joachim Krebs has been working in the field of calcium-binding and calcium-transporting proteins for many years. After receiving his PhD, he spent two years as
a Post-doctoral fellow in the lab of Prof. RJP Williams at Oxford, UK. In 1977, he has accepted a staff position at the Institute of Biochemistry at the Swiss Federal
Institute of Technology (ETH) in Zürich, Switzerland. He was lecturing different courses in Biochemistry and Biophysics and was leading a lab working on the
structure-function relationship of calcium-binding and calcium-transporting proteins. After retirement from the ETH he continued his research as a consultant of the
Lab of Prof. Christian Griesinger at the MPI in Göttingen, Germany. He has authored, co-authored and edited numerous articles in international journals. Recently
he edited a book on “Calcium: A matter of life or death” published in 2007. He serves as the Editorial Board Member of BBA Molecular Cell Research and Archives
of Biochemistry and Biophysics.