skin-diseases-and-microbiology-2016_scientifictracks

14 / 20

Volume 4, Issue 7(Suppl) J Infect Dis Ther 2016
ISSN: 2332-0877, JIDT an open access journal
Page 38
Notes:
Skin Diseases & Microbiology 2016
October 03-05, 2016
conferenceseries.com
October 03-05, 2016 Vancouver, Canada
International Conference on
Infectious Diseases, Diagnostic Microbiology &
Dermatologists Summit on Skin Infections
Application of Adipose Derived Progenitor Cells for Treatment of Chronic Wounds
R B Jalili
University of British Columbia, Canada
Introduction: Chronic wounds such as diabetic foot ulcers usually fail to progress through the normal wound healing process.
Despite widespread effort, current conventional prevention and treatment methods have neither decreased prevalence of these ulcers
nor significantly improved their outcomes. This speaks to the need for development of innovative and clinically translatable strategies
for treatment of chronic wounds. Stem cell therapy has been examined as a therapeutic approach to chronic wounds throughout
the past decade. The use of Adipose derived cells (ADCs) in treatment of chronic wounds has been both promising and practical
treatment because of its relatively non-invasive extraction, high proliferation rate, and ability to differentiate into several mesodermal
lineages. It has been shown that wounds treated with ADCs applied in the combination of a three-dimensional scaffold exhibit the
greatest wound healing outcome.
Methods: In this study, we developed a novel bio-hybrid system comprising an injectable biocompatible crosslinked matrix that is
populated with adipose derived cells to form a scaffold within the wound bed. Layers of a nano-woven biopolymer mesh were then
served to enhance graft toughness and restore tissue homeostasis ultimately improving the rate of healing of a chronic wound. We
compared the viability of adipose derived cells in vitro in combination with and without this bioengineered in-situ forming skin
substitute and then applied it in treatment of full-thickness wounds in a pilot murine chronic wound model.
Results: Adipose derived cells (ADCs) exhibited greater viability and functional characteristics when cultured with the bioengineered
skin substitute than those cultured alone. Gross wound measurements of the wound treated with combination of ADCs and
bioengineered skin substitute exhibited significantly improved wound healing than untreated wounds or those that were treated with
ASCs alone. Future research is warranted to examine the promising use of ADCs as treatment for chronic wounds.
Conclusion: Our bottom-up approach will integrate fundamental aspects of biomaterials design with cellular and molecular medicine
to innovate an affordable and employable, novel system for the treatment of chronic wounds.
Biography
Dr Jalili is an Assistant Professor in the Department of Surgery at the University of British Columbia. He is a Principal Investigator at ICORD. Dr. Jalili attended the Tehran
University of Medical Sciences for his M.D. and the University of British Columbia for his Ph.D. in Experimental Medicine.
R B Jalili, J Infect Dis Ther 2016, 4:7(Suppl)