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Volume 7, Issue 5 (Suppl) J Community Med Health Educ
ISSN: 2161-0711 JCMHE, an open access journal Public Health Congress 2017
November 13-14, 2017
November 13-14, 2017 Osaka, Japan
3rd World Congress on
Public Health, Nutrition & Epidemiology
Zinc transporter SLC39A11 polymorphisms are associated with chronic gastritis in the Korean genome
and epidemiology study (KoGES)
Ji-Hyun Bae and Eunyoung
Keimyung University, Republic of Korea
Statement of the Problem: To determine and search for the genes that are associated with gastritis and are possible therapeutic
targets for precision nutrition.
Methodology & Theoretical Orientation: Participants in this cross-sectional study (n = 3882 + 252) were from a cohort of
the Korean Genome Epidemiology Study (KoGES) in 2001. Theage, gender, education, smoking and drinking status, exercise,
stress, and income level for all participants were determined via questionnaire. Demographic and anthropometric data were
collected. Fasting blood samples were collected to determine serum levels of glucose, insulin, total bilirubin, total cholesterol,
HDL-cholesterol, and triglycerides. The presence of chronic gastritis was defined as confirmed diagnosis by a physician. Food
consumption was determined using a semi-quantitative food frequency questionnaire.
Results: (1) We found eight different single nucleotide polymorphisms (SNPs) that are significantly different between
subjects without gastritis and those with gastritis. Of eight SNPs, three [rs17183225 (C/T), rs17780814 (A/C), and rs17780820
(A/G)] are closely located in the intronic region of zinc transporter SLC39A11, commonly known as ZIP11 and show linkage
disequilibrium (D´=1.0). (2) We also found that participants with (TCA+TCG) haplotype of ZIP11, at high levels of dietary
intake of spicy foods, showed a significantly increasing tendency in odds of being having chronic gastritis when compared
with those with CAA haplotype (OR 2.620; 95% CI, 1.207-5.689). (3) Demographics analyses revealed that education, exercise,
income, and stress levels are associated with the presence of gastritis (all P < 0.001). After adjusting for confounding factors,
BMI, fasting glucose, macronutrient intakes, riboflavin, and coffee drinking are associated with gastritis (all P < 0.05). We also
found positive associations between higher meal frequency and lower spicy food preference and gastritis.
Conclusions: Zinc transporter gene ZIP11 is associated with chronic gastritis in the Korean population and may interact with
spicy food, which suggests ZIP11 as a therapeutic target for precision nutrition.
Biography
Ji-Hyun Bae is a professor of Food Science and Nutrition at Keimyung University in Korea.She is an associate editor in Journal of Advanced Nutrition and Human
Metabolism, and was a visiting Professor of Pediatrics - Harvard Medical School/Massachusetts General Hospital
Ji-Hyun Bae et al., J Community Med Health Educ 2017, 7:5 (Suppl)
DOI: 10.4172/2161-0711-C1-031