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conferenceseries.com
March 22-23, 2017 | Rome, Italy
2nd World Congress on
Public Health & Nutrition
Volume 7, Issue 1 (Suppl) J Community Med Health Educ 2017
ISSN: 2161-0711, JCMHE an open access journal Public Health 2017
March 22-23, 2017
ASSOCIATION OF rs1800795 POLYMORPHISM OF IL-6 GENE WITH HEALTH STATUS IN
CROATIAN ELDERLY POPULATION
Petra Krajacica, Tatjana Skaric-Jurica, Matea Zajc Petranovica, Zeljka Tomasa, Spomenka Tomek-Roksandicb and Nina Smolej Narancicb
aInstitute for Anthropological Research, Croatia
bTeaching Institute of Public Health “A. Stampar”, Croatia
Increases in serum cytokine IL-6 have been proposed as a reliable marker of functional decline, morbidity and mortality in old age.
The results of studies exploring the role of rs1800795 polymorphism of IL-6 gene in longevity have however been conflicting. The
aim of this study was to test the association between the rs1800795 and indicators of biological age in 324 oldest old people living
in institutions (85-101 yrs). Analysis of a wide spectrum of variables associated with health status included noninvasive biometric
measurements (anthropometry, blood pressure measurement, ultrasound bone densitometry), common biochemical blood tests
(lipid, glycemic and protein status) and self-rated health. Altogether 41 variables were entered into the principal component analysis
(PCA), which resulted in the extraction of four significant factors, among which the first factor represents body mass and composition,
the second one represents sex differences, while the third one represents general health. This study revealed a significant association of
rs1800795 with the factor of general health in Croatian elderly sample indicating that the high IL-6 producer genotype (GG) carriers
have better scores in personal independence, motility and self-rated health, suffer less from chronic and acute illness and use fewer
medications. In conclusion, significant association of rs1800795 polymorphism with biological age variables in the 85+ year olds
indicates a pleiotropic effect of IL-6 gene on human health. Targeted studies are needed to explore further this relation in different
elderly populations.
Biography
Petra Krajacic is Ph.D. student at Faculty of science (Department of Biology, Zagreb University, Croatia). In her dissertation she conducted an association study
of four most important polymorphisms of longevity genes (p53, IL-6, TNF, SIRT1) and diverse phenotypic traits, like motility, independence, life satisfaction and
the presence of age- related disease, of 325 very old age people (85+). This research is a part of a Complex traits variation and health in children, adults and
centenarians project founded by the Ministry of Science, Education and Sports.
Petra Krajacic et al., J Community Med Health Educ 2017, 7:1 (Suppl)